In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 46, No. 7-8 ( 1991-8-1), p. 673-677
Abstract:
The comparative anthelmintic activity of a possible prodrug, 2,2′-dicarbomethoxyamino-5,5′-dibenzimidazolyl methanol (2) with its parent compound 2,2′-dicarbomethoxyamino-5,5′-dibenzimidazolyl ketone (1) and the reference drug mebendazole (3 a) is reported. At a dose of 25 mg/kg, compound 2 was 100% effective against Ancylostoma ceylanicum in hamsters. Compound 2 also exhibited a similar order of activity against Syphacia obvelata, Hymenolepis nana and H. diminuta at a dose of 100 mg/kg. The drug exhibited lethal effects against metamorphic forms of A. ceylanicum at a dose of 100 mg/kg. However the trichostrongylids, Nippostrongylus brasiliensis remained unaffected up to a dose of 250 mg/kg of 2. Both 1 and 3 a exhibited inferior activity than 2 except against adult A. ceylanicum. The activity of 1 and 2 has been explained on the basis of their ability to resist systemic hydrolysis resulting in higher concentration of the active drug in biophase.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-1991-7-826
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1991
detail.hit.zdb_id:
2078107-6
SSG:
12
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