In:
Blood, American Society of Hematology, Vol. 109, No. 7 ( 2007-04-01), p. 3076-3079
Abstract:
CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10−MUM1+ with 119 typical CD10+MUM1− FLs. All CD10−MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10−MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1− typical FLs (67.0 versus 58.7 years, P 〈 .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P 〈 .001), diffuse proliferation (59% vs 19%, P 〈 .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P 〈 .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10−MUM1+ FL is different from typical FL with respect to biologic and clinical features.
Type of Medium:
Online Resource
ISSN:
0006-4971
,
1528-0020
DOI:
10.1182/blood-2006-09-045989
Language:
English
Publisher:
American Society of Hematology
Publication Date:
2007
detail.hit.zdb_id:
1468538-3
detail.hit.zdb_id:
80069-7
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