In:
Otolaryngology–Head and Neck Surgery, Wiley, Vol. 139, No. 2 ( 2008-08), p. 211-215
Abstract:
To investigate the expression and clinical significance of MMP‐2, MMP‐7, MMP‐9, and TIMP‐1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS). STUDY DESIGN Prospective study. SUBJECTS AND METHODS This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined. RESULTS Expression of MMP‐2 was found significantly increased in NP, whereas MMP‐7 expression was found significantly increased in CRS ( P 〈 0.001). TIMP‐1 was significantly high in control group compared to CRS and NP ( P 〈 0.001 and P = 0.002, respectively). CONCLUSIONS Different regulation type of activation of MMPs has been found in these two diseases. If MMP‐2 expression is intense in the mucosa, then this ends with polyp formation; if MMP‐7 expression is intense, it ends with CRS or stays as CRS.
Type of Medium:
Online Resource
ISSN:
0194-5998
,
1097-6817
DOI:
10.1016/j.otohns.2008.04.032
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2008453-5
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