In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 6 ( 2021-6-15), p. e0009156-
Abstract:
The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with different pre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was a lack of systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients with various RRT. Methodology/Principal findings We searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. The global COVID-19 data were retrieved from the international database on June 30, 2020, for estimating the prevalence and CFR of the general population as referencing points. Of 3,272 potential studies, 34 were eligible studies consisted of 1,944 COVID-19 confirmed cases in 21,873 ESRD patients with RRT from 12 countries in four WHO regions. The overall pooled prevalence in ESRD patients with RRT was 3.10% [95% confidence interval (CI) 1.25–5.72] which was higher than referencing 0.14% global average prevalence. The overall estimated CFR of COVID-19 in ESRD patients with RRT was 18.06% (95% CI 14.09–22.32) which was higher than the global average at 4.98%. Conclusions This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT should have their specific protocol of COVID-19 prevention and treatment to mitigate excess cases and deaths.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009156
DOI:
10.1371/journal.pntd.0009156.g001
DOI:
10.1371/journal.pntd.0009156.g002
DOI:
10.1371/journal.pntd.0009156.g003
DOI:
10.1371/journal.pntd.0009156.g004
DOI:
10.1371/journal.pntd.0009156.g005
DOI:
10.1371/journal.pntd.0009156.g006
DOI:
10.1371/journal.pntd.0009156.g007
DOI:
10.1371/journal.pntd.0009156.g008
DOI:
10.1371/journal.pntd.0009156.g009
DOI:
10.1371/journal.pntd.0009156.t001
DOI:
10.1371/journal.pntd.0009156.s001
DOI:
10.1371/journal.pntd.0009156.s002
DOI:
10.1371/journal.pntd.0009156.s003
DOI:
10.1371/journal.pntd.0009156.s004
DOI:
10.1371/journal.pntd.0009156.s005
DOI:
10.1371/journal.pntd.0009156.s006
DOI:
10.1371/journal.pntd.0009156.s007
DOI:
10.1371/journal.pntd.0009156.r001
DOI:
10.1371/journal.pntd.0009156.r002
DOI:
10.1371/journal.pntd.0009156.r003
DOI:
10.1371/journal.pntd.0009156.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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