In:
Korean Journal of Food Preservation, The Korean Society of Food Preservation, Vol. 28, No. 6 ( 2021-10), p. 828-836
Abstract:
To test the potential use of the fern Pyrrosia lingua as an
anti-inflammatory functional material, we examined the effects of P. lingua ethanol extract (PLE) on RAW 264.7 macrophages treated with
the pro-inflammatory molecule lipopolysaccharide (LPS). Notably, up to 100 μg/mL PLE did not result in any discernable inhibition of cellular
metabolic activity or cytotoxicity in the macrophages. However, supplementing LPS-treated RAW 264.7 macrophages with PLE significantly suppressed various
pro-inflammatory responses in a dose-dependent manner, including i) phosphorylation of nuclear factor-kappa B (NF-κB) subunit p65; ii)
accumulation of inducible nitric oxide synthase and cyclooxygenase-2; iii) expression of pro-inflammatory mediators, including prostaglandin E synthase 2
and nitrite; and iv) expression of pro-inflammatory biomarker genes, including interleukin 1 beta, interleukin 6, tumor necrosis factor-alpha, and monocyte
chemoattractant protein-1. Taken together, our results indicate that PLE regulates NF-κB signaling and inhibits cytokine production. Therefore,
the use of domestic biological resources like could be increased P. lingua as a novel functional material.
Type of Medium:
Online Resource
ISSN:
1738-7248
,
2287-7428
Uniform Title:
Raw 264.7 macrophages에 대한 Pyrrosia lingua 추출물의 항염증
효과
DOI:
10.11002/kjfp.2021.28.6.828
Language:
English
Publisher:
The Korean Society of Food Preservation
Publication Date:
2021
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