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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  BMC Musculoskeletal Disorders Vol. 24, No. 1 ( 2023-09-28)
    In: BMC Musculoskeletal Disorders, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-09-28)
    Abstract: To investigate the differences of patellofemoral joint pressure and contact area between the process of stair ascent and stair descent. Methods The finite element models of 9 volunteers without disorders of knee (9 males) to estimate patellar cartilage pressure during the stair ascent and the stair descent. Simulations took into account cartilage morphology from magnetic resonance imaging, joint posture from weight-bearing magnetic resonance imaging, and ligament model. The three-dimension models of the patella, femur and tibia were developed with the medical image processing software, Mimics 11.1. The ligament was established by truss element of the non-linear FE solver. The equivalent gravity direction (-z direction) load was applied to the whole end of femur (femoral head) according to the body weight of the volunteers, and the force of patella was observed. A paired-samples t -test or Wilcoxon rank sum test to make comparisons between stair ascent and stair descent. Statistical analyses were performed using SPSS 22.0 using a P value of 0.05 to indicate significance. Results During the stair descent (knee flexion at 30°), the contact pressure of the patella was 2.59 ± 0.06Mpa. The contact pressure of femoral trochlea cartilage was 2.57 ± 0.06Mpa. During the stair ascent (knee flexion at 60°), the contact pressure with patellar cartilage was 2.82 ± 0.08Mpa. The contact pressure of the femoral trochlea cartilage was 3.03 ± 0.11Mpa. The contact area between patellar cartilage and femoral trochlea cartilage was 249.27 ± 1.35mm 2 during the stair descent, which was less than 434.32 ± 1.70mm 2 during the stair ascent. The area of high pressure was located in the lateral area of patella during stair descent and the area of high pressure was scattered during stair ascent. Conclusion There are small change in the cartilage contact pressure between stair ascent and stair descent, indicating that the joint adjusts the contact pressure by increasing the contact area.
    Type of Medium: Online Resource
    ISSN: 1471-2474
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041355-5
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2017
    In:  The Knee Vol. 24, No. 2 ( 2017-03), p. 231-236
    In: The Knee, Elsevier BV, Vol. 24, No. 2 ( 2017-03), p. 231-236
    Type of Medium: Online Resource
    ISSN: 0968-0160
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2008020-7
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  • 3
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Orthopaedic Surgery and Research Vol. 18, No. 1 ( 2023-03-21)
    In: Journal of Orthopaedic Surgery and Research, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2023-03-21)
    Abstract: Patellar height is a risk factor for patellar instability, correlated with the tibia length/femur length (T/F) ratio. This study aimed to explore the changes in the T/F ratio in patients with patella instability and the potential correlation with the morphology of the patellofemoral joint and extensor moment arm. Method A retrospective analysis was performed to assess the ratio of lower limb length morphological characteristics of the patellofemoral by full weight-bearing long-leg standing radiographs, magnetic resonance imaging, and computed tomography in 75 patients with patellar instability and 75 participants from a randomly selected control group from January 2020 to September 2021. A total of eight parts were measured, including mechanical tibia length/femur length (mT/F) ratio, anatomical tibia length/femur length (aT/F) ratio, hip–knee–ankle angle, femoral neck-shaft angle, femoral valgus cut angle, patellar height, Dejour classification, sulcus angle, trochlear angle, medial trochlear inclination, lateral trochlear inclination, patella tilt angle and patellar tendon moment arm to evaluate the difference of morphology between patient group and control groups. Results The mT/F (0.840 ± 0.031 vs. 0.812 ± 0.026, p   〈  0.001) and aT/F (0.841 ± 0.033 vs. 0.808 ± 0.028, p   〈  0.001) ratios in the patient group were significantly greater than that in the control group. There was a significant correlation between patellar height and increased mT/F and aT/F ratios ( p   〈  0.05). Conclusion Patients with patellar instability had a larger lower limb length ratio, and the change in lower limb length ratio was correlated with patellar height. Level of evidence IV .
    Type of Medium: Online Resource
    ISSN: 1749-799X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2252548-8
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  • 4
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2023
    In:  The Journal of Knee Surgery Vol. 36, No. 04 ( 2023-03), p. 382-388
    In: The Journal of Knee Surgery, Georg Thieme Verlag KG, Vol. 36, No. 04 ( 2023-03), p. 382-388
    Abstract: Patellofemoral arthroplasty (PFA) is acknowledged as the method for the treatment of isolated patellofemoral osteoarthritis (PFOA). Few previous studies have assessed the patient-reported outcomes (PROs) and risk factors of less improvement of PROs in patients undergoing PFA. A retrospective analysis was performed, including all patients who had undergone PFA. Pre- and postoperative PROs included the Oxford Knee Score (OKS) and Kujala score. Univariate and multivariate statistical analyses were performed to assess influencing factors of less improvement of PROs including the demographic factors (gender, age, body mass index, smoking, opioid usage, and duration of symptoms [DOSs]), surgical factors (concomitant surgery), and imaging factors (trochlear dysplasia [TD] , patellar height, the degree of PFOA). A total of 46 PFAs were analyzed with a mean follow-up of 37 ± 7 months. The mean age at surgery was 61.1 ± 7.7 years. Patients showed significant improvement in all PROs (p  〈  0.001). Patients with TD preoperatively have greater improvement in OKS and Kujala score postoperatively (19.2 ± 5.0 vs. 23.1 ± 3.6, p = 0.038). Longer DOSs (≥1 year) had a greater mean improvement in OKS and Kujala score (p = 0.011 and p = 0.000). According to the measurement of patella height, patients with patella alta (Caton–Deschamps index [CDI] ≥1.3) showed less improvement in both OKS and Kujala score (p = 0.000 and p = 0.002). PFA is a safe and efficient surgery with good PROs. Patella alta with a CDI ≥1.3 and duration of preoperative symptoms ≤ 1 year were risk factors for decreased OKS and Kujala score improvement, while the preoperative presence of TD was significantly predictive factors for increased OKS improvement.
    Type of Medium: Online Resource
    ISSN: 1538-8506 , 1938-2480
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  The American Journal of Sports Medicine Vol. 51, No. 11 ( 2023-09), p. 2975-2985
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 51, No. 11 ( 2023-09), p. 2975-2985
    Abstract: Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease among the aged population. However, current treatments for OA are limited to alleviating symptoms, with no therapies that prevent and regenerate cartilage deterioration. Purpose: To assess the effects of platelet-derived exosomes (Plt-exos) on OA and then to explore the potential molecular mechanism. Study Design: Controlled laboratory study. Methods: Exosomes derived from human apheresis platelets were isolated and identified. The effects of Plt-exos in protecting chondrocytes under interleukin 1β stimulation were evaluated by analyzing the proliferation and migration in human primary chondrocytes. RNA sequencing was later performed in vitro for primary chondrocytes to reveal the underlying mechanisms of Plt-exo treatment. Anterior cruciate ligament transection was used to construct an OA mice model, and intra-articular injection of Plt-exos was given once a week for 6 weeks. Mice were sacrificed 4 weeks after the last injection. Histologic and immunohistochemistry staining and micro–computed tomography analysis were performed to assess alterations of articular cartilage and subchondral bone. Results: Plt-exos significantly promoted proliferation and migration of chondrocytes within a dose-dependent manner, as well as dramatically promoted cartilage regeneration and attenuated abnormal tibial subchondral bone remodeling, thus slowing the progression of OA. After being treated with Plt-exos, 1797 genes were differentially expressed in chondrocytes (923 upregulated and 874 downregulated genes). Functional enrichment results and hub genes were mainly involved in anti-inflammatory effects, mediating cell adhesion, stimulating cartilage repair, promoting anabolism, and inhibiting catabolism. Conclusion: Our results demonstrated that Plt-exos promoted chondrocyte proliferation and migration in vitro, as well as attenuated cartilage degeneration, improved the microarchitecture of subchondral bone, and retarded OA progression in vivo. Clinical Relevance: Our study illustrated that the administered Plt-exos could alleviate knee OA by attenuating cartilage degeneration and subchondral bone loss, possibly serving as a novel promising treatment for OA in the future.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2022-11-1)
    Abstract: Medial patellofemoral ligament (MPFL) reconstruction is an important surgical therapy for recurrent patellar dislocation. However, few studies have focused on exercise therapy after MPFL reconstruction. Therefore, the first purpose was to compare the active and traditional postoperative exercise therapies on the recovery of knee joint function and reduction of muscle atrophy after MPFL reconstruction, and the second purpose was to compare the active and traditional postoperative exercise therapies on the patellar stability after MPFL reconstruction. Methods The cases of 31 patients with recurrent patellar dislocation treated with patella double semi-tunnel anatomical MPFL reconstruction from February 2016 and February 2019 were retrospectively reviewed. The clinical outcomes, including the patellar tilt angle (PTA), lateral patellofemoral angle (LPFA), thigh circumference reduction, Kujala score, and Lysholm score, were compared between two groups (i.e., active exercise and traditional exercise groups) preoperatively, 3 months postoperatively, 6 months postoperatively, 12 months postoperatively, and 24 months postoperatively. Results The Kujala score was significantly higher in the active exercise group than traditional exercise group 3 months postoperatively (80.06 vs. 74.80, P   & lt; 0.01), 6 months postoperatively (89.19 vs. 82.07, P   & lt; 0.01), 12 months postoperatively (91.43 vs. 86.60, P   & lt; 0.01), and 24 months postoperatively (92.50 vs. 90.27, P  = 0.02). Similarly, there was a higher Lysholm score in the active exercise group compared with traditional exercise group 3 months postoperatively (81.25 vs. 76.53, P   & lt; 0.01), 6 months postoperatively (89.81 vs. 84.80, P   & lt; 0.01), 12 months postoperatively (93.25 vs. 88.40, P   & lt; 0.01), and 24 months postoperatively (93.69 vs. 90.67, P   & lt; 0.01). Significantly lower thigh circumference reduction was reported in the active exercise group compared with that in the traditional exercise group 3 months postoperatively (1.90 ± 0.57 vs. 2.45 ± 0.45, P   & lt; 0.01) and 6 months postoperatively (1.50 ± 0.31 vs. 1.83 ± 0.32, P   & lt; 0.01). No statistical difference was observed between the two groups in terms of PTA ( P   & gt; 0.05) or LPFA postoperatively ( P   & gt; 0.05). Conclusions Our results suggested that active exercise therapy might benefit the early recovery of knee joint function and reduction of muscle atrophy in patients with recurrent patellar dislocation after MPFL reconstruction.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2773823-1
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  • 7
    In: The Knee, Elsevier BV, Vol. 23, No. 5 ( 2016-10), p. 826-829
    Type of Medium: Online Resource
    ISSN: 0968-0160
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2008020-7
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  • 8
    Online Resource
    Online Resource
    International Scientific Information, Inc. ; 2019
    In:  Medical Science Monitor Vol. 25 ( 2019-06-12), p. 4370-4376
    In: Medical Science Monitor, International Scientific Information, Inc., Vol. 25 ( 2019-06-12), p. 4370-4376
    Type of Medium: Online Resource
    ISSN: 1643-3750
    Language: English
    Publisher: International Scientific Information, Inc.
    Publication Date: 2019
    detail.hit.zdb_id: 2060401-4
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  • 9
    In: Journal of Advanced Research, Elsevier BV, Vol. 23 ( 2020-05), p. 143-149
    Type of Medium: Online Resource
    ISSN: 2090-1232
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2541849-X
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2019
    In:  Knee Surgery, Sports Traumatology, Arthroscopy Vol. 27, No. 11 ( 2019-11), p. 3650-3659
    In: Knee Surgery, Sports Traumatology, Arthroscopy, Springer Science and Business Media LLC, Vol. 27, No. 11 ( 2019-11), p. 3650-3659
    Type of Medium: Online Resource
    ISSN: 0942-2056 , 1433-7347
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 1473170-8
    SSG: 31
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