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  • Kanayama, Naohiro  (3)
  • Kobayashi, Hiroshi  (3)
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  • 1
    Online Resource
    Online Resource
    Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism
    Wiley ; 2017
    In:  Journal of Obstetrics and Gynaecology Research Vol. 43, No. 12 ( 2017-12), p. 1815-1820
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 43, No. 12 ( 2017-12), p. 1815-1820
    Abstract: We aimed to evaluate the clinical usefulness of serum squamous cell carcinoma (SCC) antigen for the diagnosis of amniotic fluid embolism (AFE). Methods Sera and information of 20 patients with AFE (autopsy‐proven AFE, four cases; clinical AFE, 16 cases) were obtained from the Japan Amniotic Fluid Embolism Registration Center at Hamamatsu University School of Medicine. As controls, we included 74 gestational‐age‐matched healthy women who gave birth to healthy newborns during the period from December 2012 to January 2014. Receiver–operator curves (ROC) were used to evaluate the diagnostic performance of SCC levels for prediction of AFE. Results Serum SCC antigen levels in women with autopsy‐proven AFE (112.0 ± 169.4 ng/mL, P = 0.001) and clinical AFE (9.5 ± 10.3 ng/mL, P = 0.004) were significantly higher than those in healthy controls with normal delivery (4.4 ± 2.2 ng/mL). On ROC analysis, the optimal cut‐off value for SCC antigen levels was 7.15 ng/mL, for which the sensitivity and specificity for AFE prediction was 60.0% and 89.2%, respectively (area under the ROC, 0.785; 95% confidence interval, 0.663–0.908; P 〈 0.001). Conclusion Serum SCC antigen may be a promising predictor of the entry of amniotic fluid into the maternal circulation, potentially serving as a candidate marker for noninvasive diagnosis of AFE.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.2017.43.issue-12
    DOI: 10.1111/jog.13453
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2079101-X
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  • 2
    Online Resource
    Online Resource
    Predictor of mortality in patients with amniotic fluid embolism
    Wiley ; 2014
    In:  Journal of Obstetrics and Gynaecology Research Vol. 40, No. 4 ( 2014-04), p. 941-945
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 40, No. 4 ( 2014-04), p. 941-945
    Abstract: The purpose of this study was to evaluate the possibility of establishing predictors of mortality in women with amniotic fluid embolism. Methods Our previous report identified eight factors associated with amniotic fluid embolism ( AFE ) fatality: dyspnea, cardiac arrest, loss of consciousness, serum sialyl Tn greater than 47 U/mL, serum interleukin‐8 greater than 100 pg/mL, vaginal delivery, multiparity and term delivery. The ratio of the number of positive fatal factors to the number of possible fatal factors in the same case was calculated as the abundance ratio, which was used because information regarding all eight factors was not retrievable for all the patients at the time of registration. The patient group was divided into four quartiles based on this abundance ratio, and the mortality rate in each quartile was compared with the overall mortality rate among the 130 patients with AFE enrolled between 1992 and 2006. The validity of this approach was confirmed in another dataset from a cohort of 38 patients with AFE in 2007. Results A statistically significant positive correlation was observed between the abundance ratio and the mortality in each quartile ( P   〈  0.01) for the patients with AFE enrolled between 1992 and 2006. This result was also found in the AFE patients enrolled in 2007 ( P   〈  0.05). Thus, an increased in the abundance ratio of the eight fatal factors resulted in an increased case fatality rate. Conclusion These data suggested that the abundance ratio of fatal factors may be a useful predictor of mortality and therefore may be expected to improve prognostic accuracy in the future.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.2014.40.issue-4
    DOI: 10.1111/jog.12278
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2079101-X
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  • 3
    Online Resource
    Online Resource
    Fatal Factors of Clinical Manifestations and Laboratory Testing in Patients with Amniotic Fluid Embolism
    S. Karger AG ; 2010
    In:  Gynecologic and Obstetric Investigation Vol. 70, No. 2 ( 2010), p. 138-144
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 70, No. 2 ( 2010), p. 138-144
    Abstract: 〈 i 〉 Aims: 〈 /i 〉 To identify factors leading to fatality of patients with amniotic fluid embolism (AFE). 〈 i 〉 Methods: 〈 /i 〉 Patients who had fatal or nonfatal AFE were registered at the Hamamatsu University School of Medicine in the Department of Obstetrics and Gynecology from 1992 to 2006. Data collected included information about demographics and clinical characteristics. The fatal factors among these data were identified using χ 〈 sup 〉 2 〈 /sup 〉 analysis and the Mann-Whitney test. 〈 i 〉 Results: 〈 /i 〉 One hundred and thirty-five patients met the criteria, which included fatal (n = 65) and nonfatal AFE (n = 70). Maternal full-term gestational weeks, multiparous and noncesarean sections were the risk factors for death found in this study (p 〈 0.01). Sialyl Tn levels (mean ± SD) in the serum of patients with fatal AFE (69.7± 126.4 U/ml) were higher compared to those with nonfatal AFE (48.3± 161.8 U/ml; p = 0.003). Each of three items (cardiac arrest, dyspnea or loss of consciousness) was more common in fatal AFE (p 〈 0.01). Maternal pregnancy and labor complications were not associated with the distinction between fatal and nonfatal AFE. 〈 i 〉 Conclusion: 〈 /i 〉 Factors associated with patients with fatal AFE were identified. These included multiparity, noncesarean section at full-term and the three symptoms mentioned above. Sialyl Tn levels could be a possible prognostic fatality factor.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000313302
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482695-1
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