In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. suppl_16 ( 2007-10-16)
Abstract:
Background: The prognostic value of non-obstructive, CT low-dense plaques (CTLDP) on multislice computed tomography (MSCT) for the prediction of nonfatal acute myocardial infarction (AMI), unstable angina and cardiac death has not yet been defined. Methods and Results: We identified 760 patients who underwent MSCT and had non-obstructive coronary artery disease were followed up for the occurrence of AMI, unstable angina and cardiac death. Non-obstructive CTLDP were defined as plaques with the CT density 〈 68 Hounsfield unit, which accompanied by mild to moderate coronary artery stenosis (25–75%). Patients were followed-up for the occurrence of acute coronary syndrome (ACS) including nonfatal AMI and unstable angina, and cardiac death for 1060 ± 539 days. CTLDP were detected in 189 patients (24.9 %). The annual event rate of AMI, unstable angina, ACS and cardiac death was 0.94 %, 1.13 %, 2.08 % and 0.37 %, respectively in patients with CTLDP and 0.05 %, 0.64%, 0.70 % and 0.23 %, respectively in patients without CTLDP. The event rate of ACS was significantly higher in patients with CTLDP than in those without CTLDP (p=0.002). Univariate Cox regression analysis disclosed that the presence of CTLDP is an independent predictor of the occurrence of ACS. Conclusion: Non-obstructive CTLDP detected by MSCT yield prognostic information toward the identification of ACS. Figure: Kaplan-Meyer curves for the ACS-free survival
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.116.suppl_16.II_770-c
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2007
detail.hit.zdb_id:
1466401-X
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