In:
International Journal of Cancer, Wiley, Vol. 137, No. 5 ( 2015-09), p. 1035-1046
Abstract:
What's new? IL‐6 plays a critical role in the progression of pancreatic cancer, and its inhibition may be key in the therapeutic battle against the disease. IL‐6 acts through both an anti‐inflammatory classic signaling pathway involving membrane‐bound IL‐6R and a pro‐inflammatory trans‐signaling pathway involving soluble IL‐6R and gp130. Using a clinically adapted xenotransplant model, this study shows that inhibition of both pathways, with either tocilizumab or sgp130Fc, which specifically blocks trans‐signaling, leads to significant reductions in human pancreatic tumor growth. Following surgical resection of primary tumors, the inhibitors decreased local tumor recurrence rates and reduced numbers of distant metastases.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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