In:
Journal of Clinical Ultrasound, Wiley, Vol. 46, No. 2 ( 2018-02), p. 122-128
Abstract:
Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age‐ and gender‐matched healthy controls. Methods The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age‐ and gender‐matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). Results In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so‐called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV‐RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P = .004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P = .001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P 〈 .001) differed significantly. Between active and nonactive acromegaly subgroups, only the time‐to‐peak LV twist (377 ± 78 vs. 229 ± 97 ms, P = .005) showed significant difference. Conclusions Acromegaly is associated with impaired LV rotation and twist as assessed by 3‐dimensional speckle tracking echocardiography. LV‐RBR is a frequent phenomenon in acromegaly.
Type of Medium:
Online Resource
ISSN:
0091-2751
,
1097-0096
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1492376-2
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