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  • 1
    Online Resource
    Online Resource
    Colorectal Carcinomas: Searching for New Histological Parameters Associated with Lymph Node Metastases
    MDPI AG ; 2023
    In:  Medicina Vol. 59, No. 10 ( 2023-10-02), p. 1761-
    Details
    In: Medicina, MDPI AG, Vol. 59, No. 10 ( 2023-10-02), p. 1761-
    Abstract: Background and Objectives: Colorectal cancer (CRC) continues to be an essential public health problem. Our study aimed to evaluate the prognostic significance of classic prognostic factors and some less-studied histopathological parameters in CRC. Materials and Methods: We performed a retrospective study on 71 colorectal carcinoma patients who underwent surgery at the “Pius Brînzeu” County Clinical Emergency Hospital in Timișoara, Romania. We analyzed the classic parameters but also tumor budding (TB), poorly differentiated clusters (PDCs) of cells, tumor-infiltrating lymphocytes (TILs), and the configuration of the tumor border on hematoxylin–eosin slides. Results: A high degree of malignancy (p = 0.006), deep invasion of the intestinal wall (p = 0.003), an advanced stage of the disease (p 〈 0.0001), lymphovascular invasion (p 〈 0.0001), perineural invasion (p 〈 0.0001), high-grade TB (p 〈 0.0001), high-grade PDCs (p 〈 0.0001), infiltrative tumor border configuration (p 〈 0.0001) showed a positive correlation with lymph node metastases. Conclusions: The analyzed parameters positively correlate with unfavorable prognostic factors in CRC. We highlight the value of classic prognostic factors along with a series of less-known parameters that are more accessible and easier to evaluate using standard staining techniques and that could predict the risk of relapse or aggressive evolution in patients with CRC.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina59101761
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2088820-X
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  • 2
    Online Resource
    Online Resource
    Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas
    Association of Basic Medical Sciences of FBIH ; 2021
    In:  Bosnian Journal of Basic Medical Sciences ( 2021-09-03)
    Details
    In: Bosnian Journal of Basic Medical Sciences, Association of Basic Medical Sciences of FBIH, ( 2021-09-03)
    Abstract: The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently,  we evaluated  associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t)  most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p 〈 0.0001), tumor stage (p=0.0003), lymphovascular invasion (p 〈 0.0001), perineural invasion (p=0.005) and the tumor border configuration (p 〈 0.0001).  High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.
    Type of Medium: Online Resource
    ISSN: 1840-4812 , 1512-8601
    URL: Article
    DOI: 10.17305/bjbms.2021.6110
    Language: Unknown
    Publisher: Association of Basic Medical Sciences of FBIH
    Publication Date: 2021
    detail.hit.zdb_id: 2548947-1
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  • 3
    Online Resource
    Online Resource
    Poorly differentiated clusters: prognostic significance in colorectal carcinomas
    Termedia Sp. z.o.o. ; 2019
    In:  Polish Journal of Pathology Vol. 70, No. 4 ( 2019), p. 235-245
    Details
    In: Polish Journal of Pathology, Termedia Sp. z.o.o., Vol. 70, No. 4 ( 2019), p. 235-245
    Type of Medium: Online Resource
    ISSN: 1233-9687
    URL: Article
    DOI: 10.5114/pjp.2019.93125
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2019
    detail.hit.zdb_id: 2048446-X
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  • 4
    Online Resource
    Online Resource
    Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases
    MDPI AG ; 2023
    In:  Medicina Vol. 59, No. 7 ( 2023-07-03), p. 1241-
    Details
    In: Medicina, MDPI AG, Vol. 59, No. 7 ( 2023-07-03), p. 1241-
    Abstract: Background and Objectives: This study aimed to assess the clinical-pathological profile of patients with invasive cutaneous melanomas and to identify the parameters with a prognostic role in the lymph nodal spread of this malignant tumor. Materials and Methods: We performed a retrospective study on patients with invasive cutaneous melanomas who underwent surgery in the “Pius Brînzeu” County Clinical Emergency Hospital from Timișoara, Romania, and were evaluated for the status of loco-regional lymph nodes. We selected and analyzed some parameters searching for their relationship with lymph node metastases. Results: We identified 79 patients with invasive cutaneous melanomas (29 men and 50 women, mean age 59.36 years). A percentage of 58.3% of melanomas had Breslow tumor thickness 〉 2 mm; 69.6% of melanomas showed a Clark level IV–V. Tumor ulceration was present in 59.5% of melanomas. A mitotic rate of ≥5 mitoses/mm2 was observed in 48.1% of melanomas. Tumor-infiltrating lymphocytes (TILs), non-brisk, were present in 59.5% of cases and 22.8% of patients had satellite/in-transit metastasis (SINTM). Tumor regression was identified in 44.3% of cases. Lymph nodes metastases were found in 43.1% of patients. Statistical analysis showed that lymph node metastases were more frequent in melanomas with Breslow thickness 〉 2 mm (p = 0.0002), high Clark level (p = 0.0026), mitotic rate 〉 5 mitoses/mm2 (p = 0.0044), ulceration (p = 0.0107), lymphovascular invasion (p = 0.0182), SINTM (p = 0.0302), and non-brisk TILs (p = 0.0302). Conclusions: The Breslow thickness 〉 2 mm, high Clark level, high mitotic rate and ulceration are the most important prognostic factors for lymph nodal spread in cutaneous melanomas. However, some melanomas without these clinical-pathological features can have an unexpected, aggressive evolution, which entails the necessity of close and prolonged clinical follow-up of patients, including those with lesions considered without risk.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina59071241
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2088820-X
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  • 5
    Online Resource
    Online Resource
    Different disease characteristics in young patients with colorectal cancer: a large retrospective study in a city in Romania
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 5 ( 2021-05), p. 030006052110166-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 5 ( 2021-05), p. 030006052110166-
    Abstract: In 2018, colorectal cancer (CRC) was the second most frequent malignancy in Romania after lung cancer. Although CRC is typically encountered in patients 〉 50 years old, CRC's global incidence among younger adults has been increasing. We aimed to compare the disease characteristics of patients with CRC aged ≤50 years with those 〉 50 years old. Methods We retrospectively evaluated data from patients with CRC who underwent standard surgery at “Pius Brinzeu” Emergency County Hospital, Timisoara, Romania. Patients were divided into two groups: Group 1 (patients ≤50 years old) and Group 2 (patients 〉 50 years old). Six parameters were analyzed (sex, residence location, age, tumor localization, microscopic findings, pathological staging). Results Data on age-related CRC were available for 1380 patients treated from January 2012 to December 2018. Group 1 included 120 patients while group 2 included 1260 patients. Significantly more Group 1 patients presented with advanced CRC compared with Group 2 patients (94.2% vs. 87.4%). Furthermore, CRC in younger adults was more likely to be diagnosed at an advanced stage. Conclusions Monitoring the CRC incidence in younger adults is essential to assess whether screening practices require changes and to raise awareness among clinicians of the increasing CRC incidence among younger patients.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211016630
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 6
    Online Resource
    Online Resource
    Three‐Dimensional Virtual Pathology Specimens: Decrease in Student Performance upon Switching to Digital Models
    Wiley ; 2022
    In:  Anatomical Sciences Education Vol. 15, No. 1 ( 2022-01), p. 115-126
    Details
    In: Anatomical Sciences Education, Wiley, Vol. 15, No. 1 ( 2022-01), p. 115-126
    Abstract: Several alternatives to formalin‐stored physical specimens have been described in medical literature, but only a few studies have addressed the issue of learning outcomes when these materials were employed. The aim of this study was to conduct a prospective controlled study to assess student performance in learning anatomic pathology when adding three‐dimensional (3D) virtual models as adjunct teaching materials in the study of macroscopic lesions. Third‐year medical students (n = 501) enrolled at the Victor Babes University of Medicine and Pharmacy in Timisoara, Romania, were recruited to participate. Student performance was assessed through questionnaires. Students performed worse with new method, with poorer results in terms of overall (mean 77.6% ±SD 11.8% vs. 83.6% ±10.5) and individual question scores (percentage of questions with maximum score 34.6% ±25.6 vs. 47.7 ± 24.6). This decreased performance was generalizable, as it was observed across all language divisions and was independent of the teaching assistant involved in the process. In an open‐ended feedback evaluation of the new 3D specimens, most students agreed that the new method was better, bringing arguments both for and against these models. Although subjectively the students found the novel teaching materials to be more helpful, their learning performance decreased. A wider implementation as well as exposure to the technique and use of virtual specimens in medical teaching could improve the students’ performance outcome by accommodating the needs for novel teaching materials for digital natives.
    Type of Medium: Online Resource
    ISSN: 1935-9772 , 1935-9780
    URL: Issue
    URL: Article
    DOI: 10.1002/ase.v15.1
    DOI: 10.1002/ase.2041
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2403787-4
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