In:
International Journal of Endocrinology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-7
Abstract:
Background . Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods . Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls. Results . In AITD, the allele frequencies of MICA*010 ( OR = 2.21 ; 95% CI, 1.30–3.76, P 〈 0.003 , P c 〈 0.042 ) were higher than those of controls. Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA*010 ( OR = 2.99 ; 95% CI, 1.47–6.08, P 〈 0.003 , P c 〈 0.042 ) and lower frequencies of MICA*008 ( OR = 0.08 ; 95% CI, 0.01–0.62, P 〈 0.001 , P c 〈 0.014 ) compared to those of controls. HLA-B*46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA*010. Analyses of the associations between MICA*010 and HLA-B*46 with AITD suggest an association of the MICA allele with AITD. Conclusions . Our results suggest that innate immunity might contribute to the pathogenesis of AITD.
Type of Medium:
Online Resource
ISSN:
1687-8337
,
1687-8345
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2502951-4
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