In:
American Journal of Reproductive Immunology, Wiley, Vol. 71, No. 5 ( 2014-05), p. 451-457
Abstract:
The aim of this study was to estimate the incidence of the disease and to analyze laboratory data of 23 newborns undergoing serologic testing for alloimmune neonatal neutropenia ( ANN ) during the 1998–2008 period in C roatia. Method of study Laboratory data on 23 newborns undergoing serologic testing for ANN during the 1998–2008 period and epidemiologic data on the number of live births in Croatia were analyzed. Laboratory testing for ANN included serologic screening of maternal and neonatal sera and granulocytes (neutrophils) by immunofluorescence ( IF ) method. The monoclonal antibody immobilization of neutrophil antigens ( MAINA ) was employed to determine anti‐ HNA antibody specificity. Results Anti‐ HNA antibodies were detected in seven (54%) of 13 cases of serologically positive ANN . Only anti‐ HLA class I antibodies were demonstrated in four (31%) of 13 cases In the 2007–2008 period of prospective data collection, the number of serologically verified ANN cases was one case per 17,323 live births. Results of the prospective study conducted at M aternity W ard, D epartment of G ynecology and O bstetrics, S estre milosrdnice U niversity H ospital C enter yielded the ANN incidence of one case per 2843 live births. Conclusion Monitoring of neutrophil count in neonatal blood and serologic testing for ANN in case of isolated neutropenia in the newborn contributed considerably to timely detection of ANN . Descriptors Neonatal alloimmune neutropenia—incidence, serologic diagnosis, antineutrophil antibodies, anti‐ HNA , anti‐ HLA class I, C roatia.
Type of Medium:
Online Resource
ISSN:
1046-7408
,
1600-0897
DOI:
10.1111/aji.2014.71.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2024667-5
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