In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-28)
Abstract:
In this study, it was aimed to investigate 149 Tb-PSMA-617 for targeted α-therapy (TAT) using a mouse model of prostate-specific membrane antigen (PSMA)-expressing prostate cancer. 149 Tb-PSMA-617 was prepared with 〉 98% radiochemical purity (6 MBq/nmol) for the treatment of mice with PSMA-positive PC-3 PIP tumors. 149 Tb-PSMA-617 was applied at 1 × 6 MBq (Day 0) or 2 × 3 MBq (Day 0 & Day 1 or Day 0 & Day 3) and the mice were monitored over time until they had reached a pre-defined endpoint which required euthanasia. The tumor growth was significantly delayed in mice of the treated groups as compared to untreated controls (p 〈 0.05). TAT was most effective in mice injected with 2 × 3 MBq (Day 0 & 1) resulting in a median lifetime of 36 days, whereas in untreated mice, the median lifetime was only 20 days. Due to the β + -emission of 149 Tb, tumor localization was feasible using PET/CT after injection of 149 Tb-PSMA-617 (5 MBq). The PET images confirmed the selective accumulation of 149 Tb-PSMA-617 in PC-3 PIP tumor xenografts. The unique characteristics of 149 Tb for TAT make this radionuclide of particular interest for future clinical translation, thereby, potentially enabling PET-based imaging to monitor the radioligand’s tissue distribution.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-54150-w
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2019
detail.hit.zdb_id:
2615211-3
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