In:
Magnetic Resonance in Medicine, Wiley, Vol. 82, No. 5 ( 2019-11), p. 1660-1670
Abstract:
To evaluate the feasibility of ferumoxytol (FE)‐enhanced UTE‐MRA for depiction of the pulmonary vascular and nonvascular structures. Methods Twenty healthy volunteers underwent contrast‐enhanced pulmonary MRA at 3 T during 2 visits, separated by at least 4 weeks. Visit 1: The MRA started with a conventional multiphase 3D T 1 ‐weighted breath‐held spoiled gradient‐echo MRA before and after the injection of 0.1 mmol/kg gadobenate dimeglumine (GD). Subsequently, free‐breathing GD‐UTE‐MRA was acquired as a series of 3 flip angles (FAs) (6°, 12°, 18°) to optimize T 1 weighting. Visit 2: After the injection of 4 mg/kg FE, MRA was performed during the steady state, starting with a conventional 3D T 1 ‐weighted breath‐held spoiled gradient‐echo MRA and followed by free‐breathing FE‐UTE‐MRA, both at 4 different FAs (6°, 12°, 18°, 24°). The optimal FA for best T 1 contrast was evaluated. Image quality at the optimal FA was compared between methods on a 4‐point ordinal scale, using multiphase GD conventional pulmonary MRA (cMRA) as standard of reference. Results Flip angle in the range of 18°‐24° resulted in best T 1 contrast for FE cMRA and both UTE‐MRA techniques ( p 〉 .05). At optimized FA, image quality of the vasculature was good/excellent with both FE‐UTE‐MRA and GD cMRA (98% versus 97%; p = .51). Both UTE techniques provided superior depiction of nonvascular structures compared with either GD‐enhanced or FE‐enhanced cMRA ( p 〈 .001). However, GD‐UTE‐MRA showed the lowest image quality of the angiogram due to low image contrast. Conclusion Free‐breathing UTE‐MRA using FE is feasible for simultaneous assessment of the pulmonary vasculature and nonvascular structures. Patient studies should investigate the clinical utility of free‐breathing UTE‐MRA for assessment of pulmonary emboli.
Type of Medium:
Online Resource
ISSN:
0740-3194
,
1522-2594
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1493786-4
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