In:
European Journal of Heart Failure, Wiley, Vol. 23, No. 11 ( 2021-11), p. 1819-1827
Abstract:
Layer‐specific global longitudinal strain (GLS) has been demonstrated to predict outcome in various patient cohorts. However, little is known regarding the prognostic value of layer‐specific GLS in the general population and whether different layers entail differential prognostic information. The aim of the present study was to investigate the prognostic value of whole wall (GLS WW ), endomyocardial (GLS Endo ), and epimyocardial (GLS Epi ) GLS in the general population. Methods and results A total of 4013 citizens were included in the present study. All 4013 had two‐dimensional speckle tracking echocardiography performed and analysed. Outcome was a composite endpoint of incident heart failure and/or cardiovascular death. Mean age was 56 years and 57% were female. During a median follow‐up time of 3.5 years, 133 participants (3.3%) reached the composite outcome. Sex modified the relationship between all GLS parameters and outcome. In sex‐stratified analysis, no GLS parameter remained significant predictors of outcome in females. In contrast, GLS WW [hazard ratio (HR) 1.16, 95% confidence interval (CI) 1.02–1.31, per 1% decrease] and GLS Epi (HR 1.19, 95% CI 1.04–1.38, per 1% decrease) remained as significant predictors of outcome in males after multivariable adjustment (including demographic, clinical, biochemistry, and echocardiographic parameters). Lastly, only in males did GLS parameters provide incremental prognostic information to general population risk models. Conclusions In the general population, sex modifies the prognostic value of GLS resulting in GLS Epi being the only layer‐specific prognosticator in males, while no GLS parameter provides independent prognostic information in females.
Type of Medium:
Online Resource
ISSN:
1388-9842
,
1879-0844
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1500332-2
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