In:
Macromolecular Bioscience, Wiley, Vol. 12, No. 3 ( 2012-03), p. 367-373
Abstract:
A biodegradable and amphiphilic copolymer, mPEG ‐b‐ P(LA ‐co‐ MAC/TMA) that contains pendant 1,2‐bidentate carboxyl groups is synthesized by thiol‐ene radical addition and is further used to chelate with the active anticancer species (DACH‐Pt) of oxaliplatin to form an mPEG ‐b‐ P(LA ‐co‐ MAC/TMA‐Pt‐DACH) complex. The polymer platinum complex can self‐assemble into micelles. In vitro studies show that the DACH‐Pt micelles display enhanced or comparable cytotoxicity against SKOV‐3 and MCF‐7 cancer cells, while they show reduced toxicity to HeLa cells compared with oxaliplatin. magnified image
Type of Medium:
Online Resource
ISSN:
1616-5187
,
1616-5195
DOI:
10.1002/mabi.201100320
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2039130-4
detail.hit.zdb_id:
2041797-4
SSG:
12
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