In:
European Journal of Organic Chemistry, Wiley, Vol. 2011, No. 23 ( 2011-08), p. 4422-4428
Abstract:
The Sonogashira cross‐coupling reaction between aryl halides and terminal alkynes was carried out smoothly in water over a thermoregulated ligand–palladium catalyst under copper‐free conditions, resulting in good to excellent yields. The Sonogashira reaction was sensitive to the electronic nature of the substituents on the aryl halides. Aryl halides with an electron‐withdrawing group showed higher reactivity than those with an electron‐donating group. Particularly, this protocol could be applied to the synthesis of liquid crystals involving trans ‐cyclohexyltolans. The products could be separated from the reaction system easily by decanting, and the catalyst was recovered in water and used directly for the next run.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2011.23
DOI:
10.1002/ejoc.201100367
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1475010-7
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