In:
Angewandte Chemie, Wiley, Vol. 135, No. 36 ( 2023-09-04)
Abstract:
A unique benzannulation strategy for regioselective de novo synthesis of densely functionalized phenols is described. Through metal‐mediated formal [2+2+1+1] cycloaddition of two different alkynes and two molecules of CO, a series of densely functionalized phenols were obtained. The benzannulation strategy allows efficient regioselective installation up to five different substituents on a phenol ring. The resulting phenols have a substitution pattern different from those obtained from Dötz and Danheiser benzannulations.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v135.36
DOI:
10.1002/ange.202307251
Language:
English
Publisher:
Wiley
Publication Date:
2023
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505872-7
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1479266-7
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