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  • 1
    Online Resource
    Online Resource
    Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme—1‐year result
    Wiley ; 2021
    In:  Acta Ophthalmologica Vol. 99, No. 3 ( 2021-05)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 99, No. 3 ( 2021-05)
    Abstract: Early detection of ocular abnormalities in newborns is essential for timely diagnosis and treatment. This study aimed to assess the 1‐year result of a multicentre prospective neonatal eye examination programme with wide‐field digital imaging system in China. Methods A multicentre collaborative prospective study group for neonatal eye screening was established in nine hospitals, including eight Maternal and Children's Hospitals, and one general hospital across China from July 2016 to June 2017. Ocular examinations were performed on newborns within 28 days after birth using a wide‐field digital imaging system. Data were reviewed and analysed. The primary outcome was the prevalence of ocular abnormalities in neonates. Results We detected 13 514 (20.91%) abnormal cases in 64 632 newborns. The most frequent abnormality was retinal haemorrhage (RH; 11.83%). Most of mild RH resolved spontaneously. Among those who were beyond retinopathy of prematurity (ROP) screening criteria of China (gestational age ≥32 w and birthweight ≥2000 g), the total number of neonates with ocular abnormality was 12 218/62 799(19.45%). 59.44% of neonatal ocular abnormalities detected (accounting for 11.56% of all the screened population) needed further interference or observation. Among them, 258 patients (0.41% of all the screened population) needed immediate or timely intervention, including congenital cataract, retinal detachment, retinoblastoma and other ocular abnormalities. One thousand and ninety‐eight patients (1.75% of all the screened neonates) should be followed up closely and needed further diagnosis or intervention if necessary, such as ROP or ROP‐like retinopathy, familial exudative vitreoretinopathy and persistent hyperplasia of primary vitreous. Five thousand nine hundred and six patients (9.4%) with minor clinical significance needed short‐term follow‐up. Conclusions This prospective multicentre study of newborn ocular examination showed a relatively high prevalence of ocular abnormalities. There are a relatively high percentage of congenital eye pathology that required further referral and treatment in those neonates who were not screened routinely. According to the benefits and risks associated with neonatal eye examinations, neonatal ocular screening programme can detect ocular abnormalities at the very early stage and may play a positive role in promoting paediatric eye health.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v99.3
    DOI: 10.1111/aos.14586
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2466981-7
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  • 2
    Online Resource
    Online Resource
    Aqueous cytokine levels associated with severity of type 1 retinopathy of prematurity and treatment response to ranibizumab
    Springer Science and Business Media LLC ; 2018
    In:  Graefe's Archive for Clinical and Experimental Ophthalmology Vol. 256, No. 8 ( 2018-8), p. 1469-1477
    Details
    In: Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Science and Business Media LLC, Vol. 256, No. 8 ( 2018-8), p. 1469-1477
    Type of Medium: Online Resource
    ISSN: 0721-832X , 1435-702X
    URL: Article
    DOI: 10.1007/s00417-018-4034-5
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1459159-5
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  • 3
    Online Resource
    Online Resource
    Screening for Retinopathy of Prematurity in China: A Neonatal Units–Based Prospective Study
    Association for Research in Vision and Ophthalmology (ARVO) ; 2013
    In:  Investigative Opthalmology & Visual Science Vol. 54, No. 13 ( 2013-12-19), p. 8229-
    Details
    In: Investigative Opthalmology & Visual Science, Association for Research in Vision and Ophthalmology (ARVO), Vol. 54, No. 13 ( 2013-12-19), p. 8229-
    Type of Medium: Online Resource
    ISSN: 1552-5783
    URL: Article
    DOI: 10.1167/iovs.13-12297
    Language: English
    Publisher: Association for Research in Vision and Ophthalmology (ARVO)
    Publication Date: 2013
    detail.hit.zdb_id: 2009858-3
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  • 4
    Online Resource
    Online Resource
    Ranibizumab Injection as Primary Treatment in Patients with Retinopathy of Prematurity
    Elsevier BV ; 2017
    In:  Ophthalmology Vol. 124, No. 8 ( 2017-08), p. 1156-1164
    Details
    In: Ophthalmology, Elsevier BV, Vol. 124, No. 8 ( 2017-08), p. 1156-1164
    Type of Medium: Online Resource
    ISSN: 0161-6420
    URL: Article
    DOI: 10.1016/j.ophtha.2017.03.018
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
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  • 5
    Online Resource
    Online Resource
    Ranibizumab injection and laser photocoagulation to treat type 1 retinopathy of prematurity after 40 weeks post menstrual age: a retrospective case series study
    Springer Science and Business Media LLC ; 2019
    In:  BMC Ophthalmology Vol. 19, No. 1 ( 2019-12)
    Details
    In: BMC Ophthalmology, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2019-12)
    Type of Medium: Online Resource
    ISSN: 1471-2415
    URL: Article
    DOI: 10.1186/s12886-019-1067-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2050436-6
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  • 6
    Online Resource
    Online Resource
    Direct Costs for Retinoblastoma Treatment During the First Year of Comprehensive Therapy in China
    SLACK, Inc. ; 2012
    In:  Journal of Pediatric Ophthalmology & Strabismus Vol. 49, No. 6 ( 2012-11), p. 353-358
    Details
    In: Journal of Pediatric Ophthalmology & Strabismus, SLACK, Inc., Vol. 49, No. 6 ( 2012-11), p. 353-358
    Abstract: To evaluate the direct costs and analyze the potential cost-driving factors in the first year of retinoblastoma treatment in China. Methods: Sixty-nine pediatric patients who received multidisciplinary treatment for retinoblastoma in three tertiary hospitals from 2006 to 2011 were included in this retrospective study. The direct costs, including costs for chemotherapy, focal therapy, anesthetic procedure, enucleation, fundus examination, hospitalization and outpatient appointment, transportation, and accommodation for family members, were obtained from medical records and interviews. Results: The average direct costs for retinoblastoma treatment was U.S. $9,422 ± 3,709 per patient during the first year. Of this amount, chemotherapy-related expenses were $2,991 ± 3,083 (31.74%), transportation and accommodation expenses were $2,560 ± 1,348 (27.17%), general anesthetic procedure was $1,081 ± 2,711 (11.48%), and enucleation was $900 ± 1,015 (9.56%). The costs for intra-arterial chemotherapy ($1,224 ± 754) and chemotherapy drugs ($517 ± 134) were major components in chemotherapy-related expenses. The retinoblastoma clinical stage and family income positively correlated with the total direct costs ( P = .0358 and .0185, respectively). Conclusion: Comprehensive treatment involving chemotherapy imposes an enormous economical burden on families affected by retinoblastoma in China.
    Type of Medium: Online Resource
    ISSN: 0191-3913 , 1938-2405
    URL: Article
    DOI: 10.3928/01913913-20120710-04
    Language: English
    Publisher: SLACK, Inc.
    Publication Date: 2012
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  • 7
    Online Resource
    Online Resource
    Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment
    Hindawi Limited ; 2017
    In:  Journal of Ophthalmology Vol. 2017 ( 2017), p. 1-8
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: Purpose. To present cases with retinopathy of prematurity (ROP), who were treated with intravitreal injection of ranibizumab (IVR) and had unpredictable asymmetric outcomes. Methods. A retrospective review was performed in infants with type 1 ROP and had bilateral IVR (0.25 mg/0.025 mL) as initial treatment. Patients were classified into the asymmetric outcome group and the symmetric outcome group. Results. Eighty-four patients (168 eyes) were included. There were 18 eyes of 9 patients (10.7%) in the asymmetric outcome group and 150 eyes of 75 patients (89.3%) in the symmetric outcome group. In the symmetric outcome group, 86 eyes (57.3%) had ROP regression, 60 eyes (40%) had reactivation requiring laser treatment, and 4 eyes (2.7%) progressed to retinal detachment requiring vitrectomy. In the asymmetric outcome group, one of the eyes of the 9 patients had ROP regression with/without reactivation after IVR, while the contralateral eyes had negative response, including remarkable posterior fibrosis, partial or total retinal detachment, and vitreous hemorrhage. There was statistically significant difference between the birth weight of the two groups. Conclusion. Contralateral eyes with ROP can take a different clinical course after ranibizumab treatment. High rate of reactivation after IVR is another concern that ophthalmologists should pay attention to.
    Type of Medium: Online Resource
    ISSN: 2090-004X , 2090-0058
    URL: Article
    DOI: 10.1155/2017/1741386
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2546525-9
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  • 8
    Online Resource
    Online Resource
    Overexpression of KAI1 inhibits retinoblastoma metastasis in vitro
    Spandidos Publications ; 2017
    In:  Oncology Letters Vol. 13, No. 2 ( 2017-02), p. 827-833
    Details
    In: Oncology Letters, Spandidos Publications, Vol. 13, No. 2 ( 2017-02), p. 827-833
    Type of Medium: Online Resource
    ISSN: 1792-1074 , 1792-1082
    URL: Article
    DOI: 10.3892/ol.2016.5507
    Language: English
    Publisher: Spandidos Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2573196-8
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  • 9
    Online Resource
    Online Resource
    Clinical Characteristics of Pediatric Patients with Ocular Toxocariasis in China
    S. Karger AG ; 2016
    In:  Ophthalmologica Vol. 235, No. 2 ( 2016), p. 97-105
    Details
    In: Ophthalmologica, S. Karger AG, Vol. 235, No. 2 ( 2016), p. 97-105
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of the study was to analyze the clinical characteristics of pediatric patients with ocular toxocariasis. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Ocular toxocariasis was diagnosed and treated in 46 children from Shanghai and surrounding provinces. The diagnosis of ocular toxocariasis was confirmed immunologically by performing an enzyme-linked immunosorbent assay on serum and/or intraocular fluid. All pediatric patients and their guardians completed a questionnaire concerning their cases and living habits. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean age of onset was 6 ± 3 years. Most children (85%) resided in rural areas, and 91% of the children had contact with adult dogs or puppies. At the first visit, visual acuity (VA) was 〈 20/200 in 36 cases, and we detected peripheral granuloma in 36 patients. In our study, the most common signs were vitritis, vitreous strands, and tractional retinal detachment. The Optomap 200Tx device detected granuloma with an 85% sensitivity, which is much higher than that of other techniques. We treated 40 cases (87%) with topical corticosteroids, while 28 patients (61%) were treated with systemic corticosteroids. Only 18 children (39%) required surgical intervention. All patients were examined and treated by the same ophthalmologists. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Preschool children in China are more often affected by toxocariasis compared with other age groups. The most common signs included unilateral granuloma and ocular inflammation. In our study, clinical manifestations were severe and complicated. At the first visit, VA was 〈 20/200 in most patients. Ocular toxocariasis was diagnosed on the basis of clinical signs and symptoms; the diagnosis was confirmed by immunological testing. Techniques using the Optomap 200Tx device can facilitate the early detection and lead to better visual prognosis.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    URL: Article
    DOI: 10.1159/000443215
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1483531-9
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  • 10
    Online Resource
    Online Resource
    Intra-Arterial Chemotherapy as Primary Treatment for Advanced Unilateral Retinoblastoma in China
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-4-7)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-4-7)
    Abstract: This study aimed to evaluate the efficacy and complications of intra-arterial chemotherapy (IAC) as a primary treatment for advanced unilateral retinoblastoma in Chinese patients. Methods This study was a retrospective review of patients with advanced unilateral retinoblastoma treated with IAC as the primary treatment. The IAC procedures were performed using a balloon-assisted technique. The clinical status and treatment complications were recorded at each visit. Kaplan–Meier analysis was performed to estimate recurrence-free survival and ocular survival. Results In total, 116 eyes of 116 patients with advanced unilateral retinoblastoma were enrolled, including 66 eyes (57%) in group D and 50 eyes (43%) in group E. All treated eyes received a mean of 3 cycles of IAC (range, 3–5), and 66% of the eyes were combined with local consolidation therapy. The median follow-up time was 39 months (range, 22–57 months). The 3-year recurrence-free survival and ocular survival rates were 68.8% (95% CI, 59.2–76.6%) and 88.5% (95% CI, 80.9–93.2%), respectively. Moreover, the 3-year ocular survival rate in group D was significantly higher than that in group E (96.9%, 76.3%; P & lt; 0.01). The common ocular complication was vitreous hemorrhage (19.8%). No deaths or severe systemic complications occurred. Conclusion Primary intra-arterial chemotherapy is effective for the treatment of advanced unilateral retinoblastoma, especially in group D, with acceptable toxicity.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    DOI: 10.3389/fmed.2022.855661
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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