In:
Clinical Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 6 ( 2013-06), p. 939-944
Abstract:
CKD is a well known poor prognostic factor in myocardial infarction (MI). This study evaluated the prognostic significance of CKD, particularly in association with increasing age, in MI patients. Design, setting, participants, & measurements This study was based on a retrospective cohort, the Korean Acute Myocardial Infarction Registry. Patients with a discharge diagnosis of MI were analyzed to investigate the association of CKD with mortality risk according to age. A total of 11,268 patients (mean age 63.0±12.6 years) were included and followed for 1 year. Results In the full cohort, 26% of patients had CKD ( n =2929). The prevalence of CKD was higher with advancing age. Eight hundred sixty-one patients (7.6%) died and the interaction for 1-year mortality between age strata and estimated GFR (eGFR) strata was significant ( P 〈 0.001). Within each age category, the absolute 1-year mortality was higher in patients with a low eGFR. However, the adjusted relative mortality risk for a low eGFR was lower with increasing age (adjusted hazard ratio [95% confidence interval] for 1-year mortality at eGFR 〈 30 ml/min per 1.73 m 2 : 4.84 [1.93−12.15], 4.53 [2.42−8.47] , 3.51 [2.42−5.09], and 3.30 [2.41−4.52] for patients aged 〈 55, 55−64, 65−74, and ≥75 years compared with those with eGFR ≥60 ml/min per 1.73 m 2 , respectively). Conclusions For all age categories, the overall mortality was significantly higher as eGFR declined. The association of a lower eGFR with mortality was weaker with increasing age, indicating that the prognostic significance of CKD in MI patients is age dependent.
Type of Medium:
Online Resource
ISSN:
1555-9041
DOI:
10.2215/CJN.06930712
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2013
detail.hit.zdb_id:
2216582-4
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