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  • 1
    Online Resource
    Online Resource
    Abstract 4451: The effects of anthocyanins from the fruit of Vitis coignetiae Pulliat on NF-κB and NF-κB-regulated gene expressions in human lung cancer cells
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Research Vol. 70, No. 8_Supplement ( 2010-04-15), p. 4451-4451
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 8_Supplement ( 2010-04-15), p. 4451-4451
    Abstract: Vitis coignetiae Pulliat (Meoru in Korea) has been used as a remedy for inflammatory diseases and various cancers. We isolated anthocyanins from Meoru. We previously suggested that anthocyanins from fruits of Vitis coignetiae Pulliat (Meoru in Korea) should have anti-invasive effects through suppression of NF-κB activation. Here, we investigated their effects on NF-κB-regulated gene products and cellular responses in human lung cancer cells. The anthocyanins inhibited NF-κB activation in a dose-dependent manner. TNF-α augmented proliferation, migration and invasion of A549 cells. The anthocyanins inhibited the augmented proliferation, migration and invasion of the cancer cells by TNF-α. We also found that the anthocyanins suppressed NF-κB-regulated proteins involved in caner proliferation, metastasis and anti-apoptosis. The anthocyanins inhibit NF-κB activity by inhibiting IκBα phosphorylation. Taken together, this study suggested that the anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit the NF-κB activation and downstream proteins, which may be a factor in their anticancer activities of fruit of Vitis coignetiae Pulliat. Keywords: anthocyanins, Vitis coignetiae Pulliat, NF-κB, cancer * This study was supported by a grant from the National R & D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (0820050) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4451.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM10-4451
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
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    detail.hit.zdb_id: 410466-3
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  • 2
    Online Resource
    Online Resource
    Abstract 4230: Anthocyanins from the fruit of Vitis coignetiae Pulliat exhibits anticancer effects on Hep 3B human hepatocelluar carcinoma cells xenografts in nude mice
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Research Vol. 71, No. 8_Supplement ( 2011-04-15), p. 4230-4230
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 4230-4230
    Abstract: Vitis coignetiae Pulliat (Meoru in Korea) has been used as a folk remedy for inflammatory diseases and cancers. Our previous in vitro study suggested that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) should have anti-cancer activities through suppression of NF-κB. Before in vivo study, we also confirmed with Hep3B human hepatocellular carcinoma cells that AIMs suppressed NF-κB-regulated gene products. Here, we investigated their effects on NF-κB-regulated gene products and cellular responses in Hep3B cell-originated tumors in athymic nude mice. Hep3B cells (1 × 106 cells/0.1 mL) were subcutaneously injected into the left flank of twelve athymic (nu/nu) male nude mice, and then the nude mice were randomly divided into two groups with six animals each. The first group of animals received intraperitoneal injection of 100 AL of 1:10 ratio of DMSO and normal saline, whereas animals of the second group received intraperitoneal injection of AIMs (5 μg/g of animal in 100 AL of 1:10 ratio of DMSO and normal saline) daily. The AIMs suppressed the tumor growth compared to control. AIMs suppressed Ki67 expression and intratumoral vessel density on immunohistochemical staining. In addition, Western blot and immunohistochemical staining revealed AIMs suppressed the NF-KB activation and NF-KB-regulated protein levels such as COX-2, XIAP, MMP-9, VEGF and ICAM which are related to cancer cell proliferation, survival, invasion and angiogenesis in Hep3B cell-originated tumors in athymic nude mice. However, the expressions of some NF-KB-regulated proteins were not significantly suppressed. Taken together, this study indicates that the AIMs have anti-cancer effects on Hep3B cell xenografts at least in part through the inhibition of NF-κB activation and downstream proteins. This study provides evidence that AIMs might have anticancer effects on human hepatocellular carcinoma. [This study was supported by a grant from the National R & D Program for Cancer Control, Ministry for Health, Welfare & Family Affairs, Republic of Korea. (0820050).] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4230. doi:10.1158/1538-7445.AM2011-4230
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2011-4230
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 3
    Online Resource
    Online Resource
    Abstract 3818: Arsenic hexaoxide (As4O6) shows anticancer effects on human colon cancer cells in vitro and in vivo
    American Association for Cancer Research (AACR) ; 2012
    In:  Cancer Research Vol. 72, No. 8_Supplement ( 2012-04-15), p. 3818-3818
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 3818-3818
    Abstract: Arsenic hexaoxide (As4O6) has been used as a folk remedy for the treatment of cancer since the late 1980's in Korea, and evidence suggests that As4O6-induced cell death pathway was different from that of As2O3. Here, we investigated the anticancer activities of As4O6 on SW620 human colon cancer cells. As4O6 induced cell death in a dose-dependent manner. The cell death was caspase-independent. In addition, the apoptosis was associated with suppression of p-Akt and activation of p-P38. As4O6 suppressed TNF-induced NF-κB activation through suppression of phosphorylation of IαB. As4O6 also suppressed NF-κB-regulated genes (Bcl-2, XIAP, and Bcl-xL) which are involved in anti-apoptosis. In animal experiments, As4O6 inhibited tumorigenicity of SW620 cells in a xenograft mouse model without showing any harmful effects on mice. As4O6 significantly inhibited intratumoral microvessel density. However, the inhibitory effects of As4O6 on NF-κB was minimal. In summary, in vitro study indicates that the As4O6 have anti-cancer effects on SW620 human colon cancer cells through inducing apoptosis by inhibiting anti-apoptotic molecules and in vivo study suggested that As4O6 should have additional anti-angiogenic activity. This study provides the evidence that As4O6 might be useful in the treatment of human colon cancer. [This study was supported by a grant from the National R & D Program for Cancer Control, Ministry for Health, Welfare & Family Affairs, Republic of Korea (0820050), and National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2011-0007389)] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3818. doi:1538-7445.AM2012-3818
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2012-3818
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2012
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    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 4
    Online Resource
    Online Resource
    Abstract 2107: Tetra-arsenic hexoxide induces G2/M cell cycle arrest, apoptosis, and autophagy via p38 MAPK- and AKT-mediated pathways in SW620 human colon cancer cells
    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Research Vol. 77, No. 13_Supplement ( 2017-07-01), p. 2107-2107
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 2107-2107
    Abstract: Tetraarsenic hexoxide (As4O6) has been used in Korean folk remedy for the treatment of cancer since the late 1980’s. Evidence suggests that As4O6 show anti-cancer effects, whose mechanisms are different from those for As2O3. However, the detailed anticancer mechanism is still unclear. Here, we investigated the anticancer effects of As4O6 on SW620 human colon cancer cells. As4O6 induced cell death in a dose-dependent manner. Flow cytometry analysis revealed that As4O6 increased the sub-G1 (apoptotic cell population) and G2/M phase population in a dose-dependent manner. Further, nuclear condensation and cleaved nuclei were also observed upon staining with Hoechst 33342 in As4O6-treated SW620 cells. Western blot revealed that As4O6 significantly down-regulated the cyclin B1, cdc 2, pro-caspases -3, -8 and -9, and up-regulated p21 and cleavage of PARP in SW620 cells. In addition, As4O6 increased the expression of death receptor 5 (DR5), suppressed Bcl-2 and XIAP family proteins, and promoted the conversion of LC3-I to LC3-II in a Beclin-1 independent manner. Interestingly, As4O6 dephosphorylated Akt and JNK and phosphorylated p38 MAPK, and the cell death was inhibited by p38 MAPK inhibitor; whereas Akt inhibitor augmented the As4O6 induced cell death, suggesting p38 MAPK and AKT were associated with As4O6-induced cell death. Taken together, these findings suggest that As4O6 induced G2/M arrest, apoptosis and autophagic cell death at least in part through p38 MAPK and AKT pathways in SW620 human colon cancer cells. This study may explain the anecdotal anticancer effects showing central necrosis with dormant status of cancers when treated by As4O6 as folk remedy. Citation Format: Won Sup Lee, Jeong Won Yun, Min Jeong Kim, Arulkumar Nagappan, Jing Nan Lu, Seong-Hwan Chang, Jae-Hoon Jeong, GonSup Kim, Jin-Myung Jung, Soon Chan Hong. Tetra-arsenic hexoxide induces G2/M cell cycle arrest, apoptosis, and autophagy via p38 MAPK- and AKT-mediated pathways in SW620 human colon cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2107. doi:10.1158/1538-7445.AM2017-2107
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2017-2107
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
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