In:
Journal of Biomaterials and Tissue Engineering, American Scientific Publishers, Vol. 12, No. 9 ( 2022-09-01), p. 1723-1731
Abstract:
We prepare giant Quantum dot-Liposome Complexes (QLCs). Quantum dots (QDs) incorporated inside liposome above 10 μ m. QLCs is made by using the electro-swelling method combined with spin coating techniques. Three types of PC lipids and asolectin lipid are used for QLCs with
HDA (hexadecylamine) coated QDs, which ranged from blue- (diameter ~2.1 nm) to red-emission (diameter ~5.0 nm). As expected, (blue- or) green-emission QDs (smaller than) comparable to the thickness of PC lipid bilayer (~4 nm) are successfully formed QLCs, but QDs bigger than that fail to reproduce. This observation is well-consistent with those reported by Gopakumar et al. Surprisingly, all QDs irrespective of their size are, contrary to PC lipids, successfully loaded into asolectin lipid bilayer. In order to understand what makes different behaviors between PC and asolectin lipids on
QLC formation, we suggest a theoretical model based on a geometrical assumptions for deformed lipid bilayer surrounding QD. The main advantage of this model is that the critical size R cr of QD radius can be decided without calculating elastic free energy. As a result, it
predicts that only QDs below the critical size (diameter ~3.0 nm) can be loaded in a typical PC-lipid, but all size of QDs can be incorporated into asolectin bilayer under the assumption of two different curvatures on deformed monolayer.
Type of Medium:
Online Resource
ISSN:
2157-9083
DOI:
10.1166/jbt.2022.3087
Language:
English
Publisher:
American Scientific Publishers
Publication Date:
2022
detail.hit.zdb_id:
2717586-8
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