In:
Bulletin of the Korean Chemical Society, Wiley, Vol. 39, No. 7 ( 2018-07), p. 853-857
Abstract:
Bruton's tyrosine kinase, a non‐receptor TEC family kinase, plays key role in B cell differentiation, proliferation, and survival. B cell receptor regulates the B cell's fate and cytokine release of B‐lineage lymphoid leukemia cells which are deeply related with the pathogenesis of B‐cell lineage of lymphoma and leukemia and autoimmune diseases. Thus, BTK protein regulation emerged as a promising therapeutic target for both various cancers and autoimmune diseases. Herein, we report the discovery of aminopyridin‐1,2,4‐triazolopyridazine derivatives as a reversible BTK inhibitor, and in vitro enzyme assay and cell based assay result were reported.
Type of Medium:
Online Resource
ISSN:
1229-5949
,
1229-5949
DOI:
10.1002/bkcs.2018.39.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2056474-0
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