In:
British Journal of Haematology, Wiley, Vol. 143, No. 5 ( 2008-12), p. 632-640
Abstract:
Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic mechanism of this blood‐induced arthropathy yields possible treatment targets and modalities useful to reduce this invalidating co‐morbidity of haemophilia. Joint bleeding leads to initially independent adverse changes in both the synovial tissue and the articular cartilage. These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa . Consequently, effective treatment strategies will have to affect both pathways.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2008.143.issue-5
DOI:
10.1111/j.1365-2141.2008.07386.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1475751-5
Permalink