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  • Jaenisch, R  (2)
  • Weiher, H  (2)
  • 1985-1989  (2)
  • 1987  (2)
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  • 1985-1989  (2)
Year
  • 1987  (2)
  • 1
    Online Resource
    Online Resource
    Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites
    American Society for Microbiology ; 1987
    In:  Journal of Virology Vol. 61, No. 2 ( 1987-02), p. 336-343
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 61, No. 2 ( 1987-02), p. 336-343
    Abstract: The chromatin conformation of mouse genome regions containing Moloney murine leukemia proviral intergration sites in two Mov mouse strains and randomly selected integration sites in virus-infected mouse 3T3 fibroblasts was analyzed. All integrations have occurred into chromosomal regions containing several DNase-hypersensitive sites, and invariably the proviral integration sites map within a few hundred base pairs of a DNase-hypersensitive site. The probability that this close association between proviral integration sites and DNase-hypersensitive sites was due to chance was calculated to be extremely low (2 X 10(-4]. Because the proviral integrations analyzed were not selected for an altered phenotype, our results suggest that DNase-hypersensitive regions are preferred targets for retrovirus integration.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/jvi.61.2.336-343.1987
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1987
    detail.hit.zdb_id: 1495529-5
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells
    American Society for Microbiology ; 1987
    In:  Journal of Virology Vol. 61, No. 9 ( 1987-09), p. 2742-2746
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 61, No. 9 ( 1987-09), p. 2742-2746
    Abstract: Moloney murine leukemia virus (M-MuLV) and M-MuLV-derived retroviral vectors are not expressed in early mouse embryos or in embryonal carcinoma cells. M-MuLV-derived mutants or M-MuLV-related variants which transduce the neomycin phosphotransferase gene can, however, induce drug resistance in embryonal carcinoma cells with high efficiency. In this study we investigated the sequences critical for retroviral gene expression in two different embryonal carcinoma cell lines, F9 and PCC4. We show that two synergistically acting sequence elements mediate expression in embryonal carcinoma cells. One of these is located within the U3 region of the viral long terminal repeat, and the second one is in the 5' untranslated region of the retrovirus. The latter element, characterized by a single point mutation, affects the level of stable RNA in infected cells, suggesting a regulatory mechanism similar to that of human immunodeficiency virus in human T cells.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/jvi.61.9.2742-2746.1987
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1987
    detail.hit.zdb_id: 1495529-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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