In:
Small, Wiley, Vol. 6, No. 10 ( 2010-05-21), p. 1131-1139
Kurzfassung:
The synthesis of 1,18‐nucleotide‐appended bolaamphiphiles (1 , 2 , 4 , and 6) is reported, in which a 3′‐phosphorylated guanidine, adenosine, thymidine, or cytidine is connected to each end of an octadecamethylene chain. Single‐component self‐assemblies and binary self‐assemblies with the complementary oligonucleotides dC 20 , dT 20 , dA 20 , and dG 20 are studied by atomic force microscopy, powder X‐ray diffraction analysis, temperature‐dependent UV absorption, circular dichroism, and attenuated total‐reflection Fourier‐transform infrared spectroscopy. The single‐component self‐assembly of 1 forms a two‐dimensional sheet, whereas the binary self‐assembly 1 / dC 20 gives helical nanofibers. Non‐helical nanofibers are observed for the single‐component self‐assemblies of 2 and 4 , and helical nanofibers form from the binary self‐assembly 2 / dT 20 . Interestingly, helical nanorod structures are obtained from the binary self‐assembly 4 / dA 20 , and the aligned nanorods form a nematic phase. The single‐component and binary self‐assemblies from 6 give unilamellar vesicles owing to a lack of stacking interaction between the cytosine moieties.
Materialart:
Online-Ressource
ISSN:
1613-6810
,
1613-6829
DOI:
10.1002/smll.200902262
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2010
ZDB Id:
2168935-0
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