In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 54, No. 7-8 ( 1999-8-1), p. 554-561
Abstract:
The (μ-oxo)(μ-carbonato)diiron(III) complex with H 2 (tfda) (H 2 (tfda) = 2-aminomethyl-tetrahydrofuran-N,N-diacetic acid) exhibited high activity for hydroxylation of 2′-deoxygua-nosine in the presence of hydrogen peroxide, giving 8-hydroxydeoxyguanosine, but its hy droxylation activity towards other nucleosides such as 2′-deoxyadenosine, adenosine or thym idine was found negligible. In the case of the Fe(III)-(ed a) complex (H 2 (eda) = 2-methoxyethylamine-N,N-diacetic acid), hydroxylation occurred mainly at the sugar site, converting 2′-deoxyguanosine to guanosine. Based on the spectroscopic and structural properties of these iron(III) compounds, it seems most likely that an intrinsic active species for hydroxylation should be an electrophilic peroxide adduct of the (μ-oxo)diiron(III) core with η 1 coordination mode, while the contribution of OH· sides is ruled out.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-1999-7-815
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1999
detail.hit.zdb_id:
2078107-6
SSG:
12
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