In:
International Journal of Cancer, Wiley, Vol. 135, No. 11 ( 2014-12), p. 2507-2515
Abstract:
What's New? The serrated neoplasia pathway has attracted considerable attention as an alternative route for colorectal cancer development. This study shows that high microRNA‐31 expression is associated with CpG island methylator phenotype (CIMP)‐high status in serrated lesions with BRAF mutation. The data also indicate that miR‐31 may play a role in sessile serrated adenoma evolution. Moreover, not only do BRAF mutation and CIMP‐high status increase gradually from the rectum to the caecum but high miR‐31 expression does, too, suggesting that miR‐31 is a key molecule in the colorectal continuum concept. These novel data shed light on details of the colorectal serrated pathway.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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