In:
Anesthesiology Research and Practice, Hindawi Limited, Vol. 2016 ( 2016), p. 1-4
Abstract:
Background . Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods . Seventy-five scheduled surgical patients were randomly allocated into three groups. The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg −1 h −1 . Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol. Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn. Results . The hypnotic doses of M2 were significantly larger (D1: 91.4 ± 30.9 , M1: 90.7 ± 26.7 , and M2: 118.4 ± 40.2 mg, resp. (mean ± SD). p 〈 0.005 ). Age and gender were selected as statistically significant covariates using general linear model-ANOVA. The blood concentration showed no significant difference among the groups ( 3.73 ± 2.34 , 4.10 ± 3.04 , and 4.7 0 ± 2.12 μ g mL −1 , resp.). Conclusion . The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925 .
Type of Medium:
Online Resource
ISSN:
1687-6962
,
1687-6970
DOI:
10.1155/2016/9178523
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2397574-X
Permalink