In:
FEBS Letters, Wiley, Vol. 154, No. 2 ( 1983-04-18), p. 351-356
Abstract:
Caldesmon, a protein originally found in chicken gizzard, was concluded also to be present in bovine aorta, uterus, and human platelets by demonstration of a protein with the following properties: (a) Ca 2+ ‐dependent calmodulin‐binding; (b) binding to F actin in such way that the binding was broken on Ca 2+ ‐dependent binding of calmodulin; (c) cross‐reactivity in immune blotting procedures with affinity‐purified antibody against gizzard caldesmon; (d) similar subunit M r ‐values on SDS‐gel to those of gizzard caldesmon. Like gizzard caldesmon, platelet caldesmon was composed of two polypeptide bands of M r 150000 and 147000, but caldesmon in aorta and uterus gave a single band of M r 150000. A polypeptide of M r 165000 that was immunologically distinct from caldesmon but, like caldesmon, bound to calmodulin and F actin in a flip‐flop fashion, was also demonstrated in aorta and uterus.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(83)80181-1
Language:
English
Publisher:
Wiley
Publication Date:
1983
detail.hit.zdb_id:
1460391-3
SSG:
12
Permalink