In:
EMBO reports, EMBO, Vol. 12, No. 10 ( 2011-10), p. 1055-1061
Kurzfassung:
R‐spondins are secreted proteins known to synergize with Wnt signalling. The authors now show that R‐spondins are ligands for LGR4 and LGR5 orphan G‐protein‐coupled receptors. Binding of R‐spondins to LGRs positively regulates both Wnt/ ‐catenin and Wnt/PCP signalling pathways in vivo.
Materialart:
Online-Ressource
ISSN:
1469-221X
,
1469-3178
DOI:
10.1038/embor.2011.175
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2011
ZDB Id:
2025376-X
SSG:
12
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