In:
Alzheimer's & Dementia, Wiley, Vol. 14, No. 10 ( 2018-10), p. 1377-1382
Abstract:
Helicobacter pylori infection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population‐based cohort. Methods Between 1997 and 2002, we measured H. pylori serum IgG titers in 4215 nondemented participants of the Rotterdam Study with a mean age of 69 years. We determined the association between H. pylori at baseline and dementia incidence until 2015, per natural log (U/mL) increase in titer, and for seropositive/seronegative, using Cox models adjusting for cohort, sex, age, education, and cardiovascular risk factors. Results During a median follow‐up of 13.3 years, 529 participants developed dementia, of which 463 had Alzheimer's disease. H. pylori was not associated with risk of dementia (hazard ratio [95% confidence interval] for antibody titer: 1.04 [0.90–1.21] ; for seropositivity 1.03 [0.86–1.22]), or Alzheimer's disease. Discussion In this community‐dwelling population, H. pylori was not associated with dementia risk.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
DOI:
10.1016/j.jalz.2018.05.005
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2211627-8
detail.hit.zdb_id:
2201940-6
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