In:
The Korean Journal of Internal Medicine, Korean Association of Internal Medicine, Vol. 38, No. 3 ( 2023-05-01), p. 372-381
Abstract:
Background/Aims: Bleeding events after percutaneous coronary intervention (PCI) have important prognostic implications. Data on the influence of an abnormal ankle-brachial index (ABI) on both ischemic and bleeding events in patients undergoing PCI are limited.Methods: We included patients who underwent PCI with available ABI data (abnormal ABI, ≤ 0.9 or 〉 1.4). The primary endpoint was the composite of all-cause death, myocardial infarction (MI), stroke, and major bleeding.Results: Among 4,747 patients, an abnormal ABI was observed in 610 patients (12.9%). During follow-up (median, 31 months), the 5-year cumulative incidence of adverse clinical events was higher in the abnormal ABI group than in the normal ABI group: primary endpoint (36.0% vs. 14.5%, log-rank test, 〈 i 〉 p 〈 /i 〉 〈 0.001); all-cause death (19.4% vs. 5.1%, log-rank test, 〈 i 〉 p 〈 /i 〉 〈 0.001); MI (6.3% vs. 4.1%, log-rank test, 〈 i 〉 p 〈 /i 〉 = 0.013); stroke (6.2% vs. 2.7%, log-rank test, 〈 i 〉 p 〈 /i 〉 = 0.001); and major bleeding (8.9% vs. 3.7%, log-rank test, 〈 i 〉 p 〈 /i 〉 〈 0.001). An abnormal ABI was an independent risk factor for all-cause death (hazard ratio [HR], 3.05; 〈 i 〉 p 〈 /i 〉 〈 0.001), stroke (HR, 1.79; 〈 i 〉 p 〈 /i 〉 = 0.042), and major bleeding (HR, 1.61; 〈 i 〉 p 〈 /i 〉 = 0.034).Conclusions: An abnormal ABI is a risk factor for both ischemic and bleeding events after PCI. Our study findings may be helpful in determining the optimal method for secondary prevention after PCI.
Type of Medium:
Online Resource
ISSN:
1226-3303
,
2005-6648
DOI:
10.3904/kjim.2022.348
Language:
English
Publisher:
Korean Association of Internal Medicine
Publication Date:
2023
detail.hit.zdb_id:
639023-7
detail.hit.zdb_id:
2500508-X
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