In:
Chemistry – A European Journal, Wiley, Vol. 24, No. 11 ( 2018-02-21), p. 2584-2587
Kurzfassung:
To date, many poly(ethylene glycol) (PEG) and poly( N ‐isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio‐inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.
Materialart:
Online-Ressource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201706034
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
1478547-X
Permalink