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1

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Impact of the COVID-19 pandemic on children and adolescents: determinants and association with quality of life and mental health—a cross-sectional study

Richard, Viviane ; Dumont, Roxane ; Lorthe, Elsa ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Child and Adolescent Psychiatry and Mental Health Vol. 17, No. 1 ( 2023-02-01)

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In: Child and Adolescent Psychiatry and Mental Health, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2023-02-01)

Abstract: The medium-term impact of the COVID-19 pandemic on the wellbeing of children and adolescents remains unclear. More than 2 years into the pandemic, we aimed to quantify the frequency and determinants of having been severely impacted by the COVID-19 pandemic and estimate its impact on health-related quality of life (HRQoL) and mental health. Methods Data was drawn from a population-based cohort of children and adolescents, recruited between December 2021 and June 2022, in Geneva, Switzerland. The Coronavirus impact scale was used to assess the multidimensional impact of the pandemic on children through parent’s report. A score higher than one standard deviation above the mean was deemed a severe impact. Parents additionally reported about their offspring HRQoL and mental health with validated scales. Determinants of having been severely impacted were assessed with logistic models, as were the associations between having experienced a severe impact and poor HRQoL or mental health. Results Out of 2101 participants aged 2–17, 12.7% had experienced a severe pandemic impact. Having a lasting health condition, a pandemic-related worsening of lifestyle habits or an unfavorable family environment were associated with having been severely impacted by the pandemic, while a previous anti-SARS-CoV-2 infection was not. Participants who had experienced a severe pandemic impact were more likely to present poor HRQoL (aOR = 3.1; 95% CI 2.3–4.4) and poor mental health (aOR = 3.9; 95% CI 2.5–6.2). Conclusion The COVID-19 pandemic may have persistent consequences on the wellbeing of children and adolescents, especially among those with health and family vulnerabilities.

Type of Medium: Online Resource

ISSN: 1753-2000

URL: Article

DOI: 10.1186/s13034-023-00563-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2379599-2

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2

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Socioeconomic conditions and children's mental health and quality of life during the COVID-19 pandemic: An intersectional analysis

Lorthe, Elsa ; Richard, Viviane ; Dumont, Roxane ; [et al.]

Elsevier BV ; 2023

In: SSM - Population Health Vol. 23 ( 2023-09), p. 101472-

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In: SSM - Population Health, Elsevier BV, Vol. 23 ( 2023-09), p. 101472-

Type of Medium: Online Resource

ISSN: 2352-8273

URL: Article

DOI: 10.1016/j.ssmph.2023.101472

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2900371-4

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3

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Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Zaballa, María-Eugenia ; Perez-Saez, Javier ; de Mestral, Carlos ; [et al.]

Elsevier BV ; 2023

In: The Lancet Regional Health - Europe Vol. 24 ( 2023-01), p. 100547-

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In: The Lancet Regional Health - Europe, Elsevier BV, Vol. 24 ( 2023-01), p. 100547-

Type of Medium: Online Resource

ISSN: 2666-7762

URL: Article

DOI: 10.1016/j.lanepe.2022.100547

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 3055963-7

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4

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Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland

Perez-Saez, Javier ; Lauer, Stephen A ; Kaiser, Laurent ; [et al.]

Elsevier BV ; 2021

In: The Lancet Infectious Diseases Vol. 21, No. 4 ( 2021-04), p. e69-e70

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 21, No. 4 ( 2021-04), p. e69-e70

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(20)30584-3

Language: English

Publisher: Elsevier BV

Publication Date: 2021

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5

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Insights into household transmission of SARS-CoV-2 from a population-based serological survey

Bi, Qifang ; Lessler, Justin ; Eckerle, Isabella ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Communications Vol. 12, No. 1 ( 2021-06-15)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-06-15)

Abstract: Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportionately misses mild and asymptomatic infections. Serologic measures are more likely to capture all previously infected individuals. We apply household transmission models to data from a cross-sectional, household-based population serosurvey of 4,534 people ≥5 years from 2,267 households enrolled April-June 2020 in Geneva, Switzerland. We found that the risk of infection from exposure to a single infected household member aged ≥5 years (17.3%,13.7-21.7) was more than three-times that of extra-household exposures over the first pandemic wave (5.1%,4.5-5.8). Young children had a lower risk of infection from household members. Working-age adults had the highest extra-household infection risk. Seropositive asymptomatic household members had 69.4% lower odds (95%CrI,31.8-88.8%) of infecting another household member compared to those reporting symptoms, accounting for 14.5% (95%CrI, 7.2-22.7%) of all household infections.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-021-23733-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2553671-0

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6

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Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection

Perez-Saez, Javier ; Zaballa, María-Eugenia ; Lamour, Julien ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Communications Vol. 14, No. 1 ( 2023-05-26)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-05-26)

Abstract: Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection against infection with pre-Omicron lineages. This has been challenged by the emergence of immune-evasive variants, notably the Omicron sublineages, in an evolving immune landscape with high levels of cumulative incidence and vaccination coverage. This in turn limits the use of widely available commercial high-throughput methods to quantify binding antibodies as a tool to monitor protection at the population-level. Here we show that anti-Spike RBD antibody levels, as quantified by the immunoassay used in this study, are an indirect correlate of protection against Omicron BA.1/BA.2 for individuals previously infected by SARS-CoV-2. Leveraging repeated serological measurements between April 2020 and December 2021 on 1083 participants of a population-based cohort in Geneva, Switzerland, and using antibody kinetic modeling, we found up to a three-fold reduction in the hazard of having a documented positive SARS-CoV-2 infection during the Omicron BA.1/BA.2 wave for anti-S antibody levels above 800 IU/mL (HR 0.30, 95% CI 0.22-0.41). However, we did not detect a reduction in hazard among uninfected participants. These results provide reassuring insights into the continued interpretation of SARS-CoV-2 binding antibody measurements as an independent marker of protection at both the individual and population levels.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-023-38744-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2553671-0

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7

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Risk of Reinfection After Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Population-based Propensity-score Matched Cohort Study

Leidi, Antonio ; Koegler, Flora ; Dumont, Roxane ; [et al.]

Oxford University Press (OUP) ; 2022

In: Clinical Infectious Diseases Vol. 74, No. 4 ( 2022-03-01), p. 622-629

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In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 74, No. 4 ( 2022-03-01), p. 622-629

Abstract: Serological assays detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are being widely deployed in studies and clinical practice. However, the duration and effectiveness of the protection conferred by the immune response remains to be assessed in population-based samples. To estimate the incidence of newly acquired SARS-CoV-2 infections in seropositive individuals as compared to seronegative controls, we conducted a retrospective longitudinal matched study. Methods A seroprevalence survey including a representative sample of the population was conducted in Geneva, Switzerland, between April and June 2020, immediately after the first pandemic wave. Seropositive participants were matched one-to-two to seronegative controls, using a propensity-score including age, gender, immunodeficiency, body mass index (BMI), smoking status, and education level. Each individual was linked to a state-registry of SARS-CoV-2 infections. Our primary outcome was confirmed infections occurring from serological status assessment to the end of the second pandemic wave (January 2021). Results Among 8344 serosurvey participants, 498 seropositive individuals were selected and matched with 996 seronegative controls. After a mean follow-up of 35.6 (standard deviation [SD] 3.2) weeks, 7 out of 498 (1.4%) seropositive subjects had a positive SARS-CoV-2 test, of whom 5 (1.0%) were classified as reinfections. In contrast, the infection rate was higher in seronegative individuals (15.5%, 154/996) during a similar follow-up period (mean 34.7 [SD 3.2] weeks), corresponding to a 94% (95% confidence interval [CI]: 86%– 98%, P & lt; .001) reduction in the hazard of having a positive SARS-CoV-2 test for seropositives. Conclusions Seroconversion after SARS-CoV-2 infection confers protection against reinfection lasting at least 8 months. These findings could help global health authorities establishing priority for vaccine allocation.

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciab495

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Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 2002229-3

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8

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A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents

Dumont, Roxane ; Richard, Viviane ; Lorthe, Elsa ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Communications Vol. 13, No. 1 ( 2022-11-29)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-11-29)

Abstract: Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence and risk factors of pediatric post-COVID in a population-based sample, stratifying by serological status. Children from the SEROCoV-KIDS cohort study (State of Geneva, Switzerland), aged 6 months to 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) and parents filled in a questionnaire on persistent symptoms in their children (lasting over 12 weeks) compatible with post-COVID. Of 1034 children tested, 570 (55.1%) were seropositive. The sex- and age-adjusted prevalence of persistent symptoms among seropositive children was 9.1% (95%CI: 6.7;11.8) and 5.0% (95%CI: 3.0;7.1) among seronegatives, with an adjusted prevalence difference (ΔaPrev) of 4.1% (95%CI: 1.1;7.3). Stratifying per age group, only adolescents displayed a substantial risk of having post-COVID symptoms (ΔaPrev = 8.3%, 95%CI: 3.5;13.5). Identified risk factors for post-COVID syndrome were older age, having a lower socioeconomic status and suffering from chronic health conditions, especially asthma. Our findings show that a significant proportion of seropositive children, particularly adolescents, experienced persistent COVID symptoms. While there is a need for further investigations, growing evidence of pediatric post-COVID urges early screening and primary care management.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-022-34616-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

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