In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 31, No. 15_suppl ( 2013-05-20), p. 4583-4583
Abstract:
4583 Background: Imaging (DCE-MRI, DCE-CT, DCE-US) provides information about the integrity and hemodynamics of the tumor microvasculature. Methods: 34 treatment (Rx) naive pts with RCC and abdominal tumor suitable for imaging received sunitinib 50 mg on a standard 4/2 schedule. DCE-US, DCE-CT, and DCE-MRI were done at baseline, during the first course and after 2wks off Rx. Imaging parameters included vessel permeability (Ktrans), extracellular volume fraction (v e ) and Ktrans/v e =Kep (by DCE-MRI), permeability surface product (PS) by DCE-CT, blood volume (BV), by DCE-CT and DCE-US and blood perfusion (by DCE-US). A morphology parameter (MP) was developed that relates flow kinetics of the microbubble contrast agent to tumor vascular morphology by DCE-US. Results: Several imaging parameters predicted for progression free survival (PFS) in responding pts (N=26). Baseline imaging parameters correlated with PFS: Ktrans by DCE-MR (Spearman r= 0.53, p=0.01, N=24), BV by DCE-CT (r=0.48, p=0.02, N=25) and disorganized vessel morphology (large MP) by DCE-US (r= - 0.45, p=0.02, N=24). Changes from baseline imaging parameters correlated with PFS: BV by DCE-US at 2 wks (r= -0.46, p=0.02, N=24), Kep by DCE-MR at 2 wks (r= -0.45, p=0.03, N=24) and MP at 1wk (r=0.67, p=0.02, N=12). There was a correlation between imaging methods: BV measured by DCE-CT correlated with BV by DCE-US (r=0.46, p=0.03, N=23) and Kep by DCE-MR (r=0.59, p=0.003, N=22); Permeability measured by DCE-MR (Ktrans) and DCE-CT (PS) correlated at 2wks (r=0.56, p=0.01, N=21). A combination of baseline US and MR parameters identified responders and non-responders with a sensitivity of 83% and specificity of 90%. Conclusions: This is the first study to contrast DCE-US, DCE-CT and DCE-MRI imaging in pts receiving antiangiogenic therapy. Baseline parameters for all three methods can predict for PFS. Changes from baseline in DCE-US and DCE-MRI parameters also predict for PFS. There is a correlation between imaging methods in parameters that measure BV and permeability. A novel DCE-US parameter was developed (MP) that quantifies the degree of tumor vascular disorganization. Baseline values in MP and changes during Rx correlate with PFS. Clinical trial information: OCT1205.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2013.31.15_suppl.4583
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2005181-5
Permalink