In:
Clinical Transplantation, Wiley, Vol. 29, No. 6 ( 2015-06), p. 547-554
Kurzfassung:
Cutaneous damage is one of the characterized manifestations in chronic graft‐versus‐host disease ( cGVHD ). When local effective immunity in the skin is altered to a dysimmune reaction, cutaneous injuries occur. Toll‐like receptor 4 signaling is regarded as a central mediator of inflammation and organ injury. In this study, we found that TLR 4 m RNA in peripheral blood from patients with cutaneous c GVHD was markedly increased compared with that from non‐ GVHD patients and healthy controls. In addition, NF ‐κ B expression, TLR 4 downstream signaling, and TLR 4‐mediated cytokines, including IL ‐6 and ICAM ‐1, were upregulated. Moreover, ICAM ‐1 was widely distributed in skin biopsies from patients with cutaneous c GVHD . We also found that LPS induced TLR 4‐mediated NF ‐κB activation and IL ‐6 and ICAM ‐1 secretion in human fibroblasts in vitro . Thus, TLR 4, NF ‐κB, IL ‐6, and ICAM ‐1 contribute to the inflammatory response that occurs in cutaneous c GVHD , indicating the TLR 4 pathway may be a novel target for cutaneous c GVHD therapy.
Materialart:
Online-Ressource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2015.29.issue-6
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2739458-X
ZDB Id:
2004801-4
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