In:
European Journal of Organic Chemistry, Wiley
Abstract:
A mild nitration of pyrrolo[2,1‐a]isoquinolines has been reached using sodium nitrite as nitro source in HFIP at ambient temperature. A variety of nitro‐bearing pyrrolo[2,1‐a] isoquinoline derivatives has been efficiently prepared in poor to quantitative yields (28‐98%). These products can be easily transformed to primary amines and amide by simple chemical reactions. Treatment of other nitrogen‐containing heterocycles such as pyrrolo[1,2‐a]quinoline and substituted indoles under this developed reaction system afforded nitro‐bearing N‐heterocycles in relativ ely lower yields (15‐19%).
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.202400116
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
1475010-7
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