In:
Journal of Chemical Research, SAGE Publications, Vol. 2008, No. 6 ( 2008-06), p. 354-356
Abstract:
A concise route to two anti-tubulin natural products combretastatin A-4 and erianin has been developed. Combretastatin A-4 was obtained by a Perkin reaction between 3-bromo-4-methoxyphenyl acetic acid and 3,4,5-trimethoxybenzaldehyde, hydroxyl transformation, decarboxylation with a high level of cis-selectivity ( cis/trans = 95/5), and erianin was obtained by subsequent hydrogenation. The overall yields of combretastatin A-4 and erianin were 37.5 and 30.8%, respectively.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.3184/030823408X324751
Language:
English
Publisher:
SAGE Publications
Publication Date:
2008
detail.hit.zdb_id:
3010810-X
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