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Data_Sheet_1.docx

Chen, Renzheng ; Yang, Jie ; Liu, Chuan ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Physiology Vol. 12 ( 2021-3-18)

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In: Frontiers in Physiology, Frontiers Media SA, Vol. 12 ( 2021-3-18)

Abstract: Acute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change and the correlation with the occurrence of AMS in different sexes are still unclear. Objectives This prospective study aimed to investigate HA induced BP responses in males and females and the relationship between AMS and 24-h ABP. Methods Forty-six subjects were matched according to demographic parameters by propensity score matching with a ratio of 1:1. All the subjects were monitored by a 24-h ABP device; the measurement was one period of 24 h BP. 2018 Lake Louise questionnaire was used to evaluate AMS. Results Both the incidence of AMS (14 [60.9%] vs. 5 [21.7%] , P = 0.007) and headache (18 [78.3%] vs. 8 [34.8%] , P = 0.003) were higher in females than in males. All subjects showed an elevated BP in the early morning [morning systolic BP (SBP), 114.72 ± 13.57 vs. 120.67 ± 11.10, P = 0.013]. The elevation of morning SBP variation was more significant in females than in males (11.95 ± 13.19 vs. −0.05 ± 14.49, P = 0.005), and a higher morning BP surge increase (4.69 ± 18.09 vs. −9.66 ± 16.96, P = 0.005) was observed after acute HA exposure in the female group. The increase of morning SBP was associated with AMS occurrence ( R = 0.662, P & lt; 0.001) and AMS score ( R = 0.664, P = 0.001). Among the AMS symptoms, we further revealed that the incidence ( R = 0.786, P & lt; 0.001) and the severity of headache ( R = 0.864, P & lt; 0.001) are closely correlated to morning SBP. Conclusions Our study demonstrates that females are more likely to suffer from AMS than males. AMS is closely associated with elevated BP in the early morning period, which may be correlated to higher headache incidence in subjects with higher morning SBP.

Type of Medium: Online Resource

ISSN: 1664-042X

URL: Article

DOI: 10.3389/fphys.2021.649211

DOI: 10.3389/fphys.2021.649211.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2564217-0

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Data_Sheet_1.docx

Cheng, Ran ; Liu, Chuan ; Yang, Jie ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Physiology Vol. 12 ( 2021-2-16)

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In: Frontiers in Physiology, Frontiers Media SA, Vol. 12 ( 2021-2-16)

Abstract: Male novel coronavirus disease (COVID-19) patients tend to have poorer clinical outcomes than female patients, while the myocardial injury is strongly associated with COVID-19-related adverse events. Owing to a lack of corresponding data, we aimed to investigate the sex differences in the incidence of myocardial injury in COVID-19 patients and to identify the potential underlying mechanisms, which may partly account for the sex bias in the incidence of adverse events. This retrospective study included 1,157 COVID-19 patients who were hospitalized in Huoshenshan Hospital from 12 March 2020 to 11 April 2020. Data on the patients’ demographic characteristics, initial symptoms, comorbidities and laboratory tests were collected. Totally, 571 (49.4%) female and 586 (50.6%) male COVID-19 patients were enrolled. The incidence of myocardial injury was higher among men than women (9.2 vs. 4.9%, p = 0.004). In the logistic regression analysis, age, and chronic kidney disease were associated with myocardial injury in both sexes. However, hypertension [odds ratio (OR) = 2.25, 95% confidence interval (CI) 1.20–4.22], coronary artery disease ( OR = 2.46, 95% CI 1.14–5.34), leucocyte counts ( OR = 3.13, 95% CI 1.24–7.86), hs-CRP ( OR = 4.45, 95% CI 1.33–14.83), and D-dimer [ OR = 3.93 (1.27–12.19), 95% CI 1.27–12.19] were independent risk factors only in the men. The correlations of hs-CRP and D-dimer with hs-cTnI and BNP were stronger in the men. The incidence of myocardial injury in COVID-19 patients is sex-dependent, predominantly in association with a greater degree of inflammation and coagulation disorders in men. Our findings can be used to improve the quality of clinical management in such settings.

Type of Medium: Online Resource

ISSN: 1664-042X

URL: Article

DOI: 10.3389/fphys.2021.632123

DOI: 10.3389/fphys.2021.632123.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

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Table_1.DOCX

Yang, Jie ; Tan, Hu ; Sun, Mengjia ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 8 ( 2022-1-7)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2022-1-7)

Abstract: Insufficient cardiorespiratory compensation is closely associated with acute hypoxic symptoms and high-altitude (HA) cardiovascular events. To avoid such adverse events, predicting HA cardiorespiratory fitness impairment (HA-CRFi) is clinically important. However, to date, there is insufficient information regarding the prediction of HA-CRFi. In this study, we aimed to formulate a protocol to predict individuals at risk of HA-CRFi. We recruited 246 volunteers who were transported to Lhasa (HA, 3,700 m) from Chengdu (the sea level [SL], & lt;500 m) through an airplane. Physiological parameters at rest and during post-submaximal exercise, as well as cardiorespiratory fitness at HA and SL, were measured. Logistic regression and receiver operating characteristic (ROC) curve analyses were employed to predict HA-CRFi. We analyzed 66 pulmonary vascular function and hypoxia-inducible factor- (HIF-) related polymorphisms associated with HA-CRFi. To increase the prediction accuracy, we used a combination model including physiological parameters and genetic information to predict HA-CRFi. The oxygen saturation (SpO 2 ) of post-submaximal exercise at SL and EPAS1 rs13419896-A and EGLN1 rs508618-G variants were associated with HA-CRFi (SpO 2 , area under the curve (AUC) = 0.736, cutoff = 95.5%, p & lt; 0.001; EPAS1 A and EGLN1 G , odds ratio [OR] = 12.02, 95% CI = 4.84–29.85, p & lt; 0.001). A combination model including the two risk factors—post-submaximal exercise SpO 2 at SL of & lt;95.5% and the presence of EPAS1 rs13419896-A and EGLN1 rs508618-G variants—was significantly more effective and accurate in predicting HA-CRFi (OR = 19.62, 95% CI = 6.42–59.94, p & lt; 0.001). Our study employed a combination of genetic information and the physiological parameters of post-submaximal exercise at SL to predict HA-CRFi. Based on the optimized prediction model, our findings could identify individuals at a high risk of HA-CRFi in an early stage and reduce cardiovascular events.

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2021.719776

DOI: 10.3389/fcvm.2021.719776.s001

DOI: 10.3389/fcvm.2021.719776.s002

DOI: 10.3389/fcvm.2021.719776.s003

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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Chen, Renzheng ; Ye, Xiaowei ; Sun, Mengjia ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 8 ( 2022-1-3)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2022-1-3)

Abstract: Background: Acute high altitude (HA) exposure results in blood pressure (BP) variations in most subjects. Previous studies have demonstrated that higher BP is potentially correlated with acute mountain sickness (AMS). The BP load may be of clinical significance regarding systemic circulation status. Objectives: This study aimed to examine HA-induced BP changes in patients with AMS compared to those in healthy subjects. Further, we provided clinical information about the relationship between variations in 24-h ambulatory parameters (BP level, BP variability, and BP load) and AMS. Methods: Sixty-nine subjects were enrolled and all participants ascended Litang (4,100 m above sea level). They were monitored using a 24-h ambulatory blood pressure device and underwent echocardiography within 24 h of altitude exposure. The 2018 Lake Louise questionnaire was used to evaluate AMS. Results: The AMS group comprised more women than men [15 (65.2%) vs. 13 (28.3%), P & lt; 0.001] and fewer smokers [4 (17.4%) vs. 23 (50.0%), P = 0.009]. The AMS group exhibited significant increases in 24-h BP compared to the non-AMS group (24-h SBP variation: 10.52 ± 6.48 vs. 6.03 ± 9.27 mmHg, P = 0.041; 24-h DBP variation: 8.70 ± 4.57 vs. 5.03 ± 4.98 mmHg, P = 0.004). The variation of mean 24-h cBPL (cumulative BP load) (mean 24-h cSBPL: 10.58 ± 10.99 vs. 4.02 ± 10.58, P = 0.016; 24-h mean cDBPL: 6.03 ± 5.87 vs. 2.89 ± 4.99, P = 0.034) was also obviously higher in AMS subjects than in non-AMS subjects after HA exposure. 24-h mean cSBPL variation (OR = 1.07, P = 0.024) and 24-h mean cDBPL variation (OR = 1.14, P = 0.034) were independent risk factors of AMS. Moreover, variation of 24-h mean cSBPL showed a good correlation with AMS score ( R = 0.504, P & lt; 0.001). Conclusions: Our study demonstrated that patients with AMS had higher BP and BP load changes after altitude exposure than healthy subjects. Excessive BP load variations were associated with AMS. Thus, BP load could be an effective indicator regarding systemic circulation status of AMS.

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2021.765422

DOI: 10.3389/fcvm.2021.765422.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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Data_Sheet_1.doc

Chen, Renzheng ; Sun, Mengjia ; Yang, Jie ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Physiology Vol. 12 ( 2021-8-27)

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In: Frontiers in Physiology, Frontiers Media SA, Vol. 12 ( 2021-8-27)

Abstract: Background: Acute high-altitude (HA) exposure results in blood pressure (BP) and cardiac function variations in most subjects, some of whom suffer from acute mountain sickness (AMS). Several previous studies have found that cardiovascular function indicators are potentially correlated with AMS. Objectives: This study aims to examine HA-induced cardiovascular adaptations in AMS patients and compare them with healthy subjects. It also aims to investigate the relationship between cardiovascular function indicators and AMS, as well as to provide some insightful information about the prevention and treatment of AMS. Methods: Seventy-two subjects were enrolled in this cohort study. All the subjects ascended Litang (4,100 m above sea level). They were monitored by a 24-h ambulatory blood pressure (ABP) device and underwent echocardiography examination within 24 h of altitude exposure. The 2018 Lake Louise questionnaire was used to evaluate AMS. Results: Acute mountain sickness group consisted of more women (17 [60.7%] vs. 10 [22.7%] , p = 0.001) and fewer smokers (5 [17.9%] vs. 23 [52.3%] , p = 0.003). Compared with subjects without AMS, subjects with AMS had lower pulse pressure (PP) (daytime PP, 45.23 ± 7.88 vs. 52.14 ± 4.75, p & lt; 0.001; nighttime PP, 42.81 ± 5.92 vs. 49.39 ± 7.67, p & lt; 0.001) and lower effective arterial elastance (Ea) (1.53 ± 0.24 vs. 1.73 ± 0.39, p = 0.023). Multivariate regression indicated that female sex (OR = 0.23, p = 0.024), lower daytime PP (OR = 0.86, p = 0.004), and lower Ea (OR = 0.03, p = 0.015) at low altitude (LA) were independent risk factors for AMS. Combined daytime PP and Ea at LA had a high predictive value for AMS (AUC = 0.873; 95% CI: 0.789–0.956). Correlation analysis showed that AMS-induced headache correlated with daytime PP ( R = −0.401, p & lt; 0.001) and nighttime PP at LA ( R = −0.401, p & lt; 0.001). Conclusion: Our study demonstrated that AMS patients had a lower PP and Ea at LA. These baseline indicators of vasodilation at LA were closely associated with AMS, which may explain the higher headache severity in subjects with higher PP at LA.

Type of Medium: Online Resource

ISSN: 1664-042X

URL: Article

DOI: 10.3389/fphys.2021.708862

DOI: 10.3389/fphys.2021.708862.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2564217-0

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