In:
Biomedical Engineering: Applications, Basis and Communications, National Taiwan University, Vol. 22, No. 04 ( 2010-08), p. 315-320
Abstract:
The present study provides in vivo trials of silicone rubber chambers filled with different concentrations (0, 1.25, 12.5, and 125 mg/ml) of Ligusticum Chuanxiong (LC) to bridge a 10 mm sciatic nerve defect in rats. Histological and electrophysiological techniques were used to evaluate the functional recovery of the nerve. At the end of eight weeks, regenerated nerves from all of the groups treated with the LC had similar microstructures compared to the controls. However, the high dose LC group at 125 mg/ml could inhibit the nerve regeneration with a significantly fewer myelinated axons compared to the other three groups. These results indicated that LC could be involved in both positive and negative effects on regenerating nerves. Therefore, whether a proper dosage of an LC is used or not plays a critical factor in deciding if it can sustain nerve regeneration over long gaps.
Type of Medium:
Online Resource
ISSN:
1016-2372
,
1793-7132
DOI:
10.4015/S1016237210002006
Language:
English
Publisher:
National Taiwan University
Publication Date:
2010
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