In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 5539-5539
Abstract:
Introduction: Malignant pleural mesotheliomas (MPMs) are aggressive tumors with a poor prognosis. Regarding tumor histology, however, the survival has been reported to be lower in patients with non-epitheloid tumors than in those with epitheloid tumors. Therefore, in order to identify molecular targets for the treatment against MPM patients, we investigated several molecules associated with epithelial to mesenchymal transition, such as Snail, Twist, E-cadherin and N-cadherin. Methods: We studied one hundred and nine patients with MPMs, including 61 epitheloid tumors (55.9%), 21 sarcomatoid tumors (19.2%), 20 biphasic tumors (18.3%) and 7 desmoplastic tumors (6.4%). Immunohistochemical assays were performed to evaluate the intratumoral expressions of Snail, Twist, E-cadherin and N-cadherin. Results: Among 109 MPMs, 41 tumors (37.6%) were Snail-high tumors, 30 tumors (27.5%) were Twist-high tumors, 18 tumors (16.5%) were E-cadherin-positive tumors, and 35 tumors (32.1%) were N-cadherin-positive tumors. Regarding tumor histology, the nuclear expression of Snail expression was significantly higher in non-epithelioid tumors than in epitheloid tumors (P & lt;0.001). Furthermore, the E-cadherin expression was significantly lower in Snail-high tumors than in Snail-low tumors (P=0.046). As a result, the E-cadherin expression was significantly lower in non-epithelioid tumors than in epitheloid tumors (P=0.013). In addition, the Snail expression was significantly higher in Twist-high tumors than in Twist-low tumors (P=0.007). The frequency of N-cadherin-positive tumors was also significantly higher in Twist-high tumors than in Twist-low tumors (P=0.005). Regarding patient survival, the overall survival was significantly lower in patients with Snail-high MPMs than in those with Snail-low MPMs (P=0.002), especially among patients with non-epitheloid tumors (P=0.009). A multivariated analysis also demonstrated that the nuclear expression of Snail was a significantly factor of a poor prognosis in MPM patients (P=0.014). Conclusions: Snail expression is associated with epithelial to mesenchymal transition and a poor prognosis in MPMs. The Snail could be a potential molecular target for the treatment of MPM patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5539. doi:1538-7445.AM2012-5539
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2012-5539
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2012
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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