In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 15_Supplement ( 2015-08-01), p. 850-850
Abstract:
Objective:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Our aim was to evaluate the effects of the hepatitis B virus (HBV) genotype, mutations, HLA single nucleotide polymorphisms (SNPs) and their interactions on HCC risk. Methods: A multi-centre case-control study of 1,507 HBV-related HCC cases and 1,560 HBV persistent carriers as controls was performed. HBV genotype, mutations and genome-wide association studies (GWAS)-identified HLA-DQ/DR SNPs (rs9272105 and rs9275319) were detected. Results: We found that the frequencies of the HBV genotypes B and BC (coinfection) were varied among the studied areas, but genotype C was consistently more frequent in HBV-related HCC (80.6% among HCC vs. 34.4% among the controls). Moreover, 11 HBV hotspot mutations in the EnhII/BCP/PC region were independently and significantly associated with HCC risk. We also detected significant interactions of HLA-DQ/DR rs9272105 with both the HBV genotype and mutations (P & lt; 0.05 for each), but there were not significant interactions for rs9275319. Through a stepwise regression analysis, the HBV genotype, the 11 mutations, HLA-DQ/DR rs9272105 and rs9275319, and the interaction of the mutation A1752G with rs9272105 were all entered into the prediction model of HCC, and the area under the curve (AUC) for the panel including the HLA-DQ/DR SNPs, HBV genotype and mutations was 0.840 (sensitivity = 81.3%, specificity = 74.8%). Conclusions: The HBV genotype, the mutations and the HLA-DQ/DR SNPs may serve as biomarkers for the surveillance of HBV persistent carriers. Large studies with prospective designs are warranted to further evaluate our results. Note: This abstract was not presented at the meeting. Citation Format: Juan Wen, Ci Song, Deke Jiang, Tianbo Jin, Xiangjun Zhai, Jianfeng Xu, Hongbing Shen, Zhibin Hu. Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 850. doi:10.1158/1538-7445.AM2015-850
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2015-850
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2015
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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