In:
Angewandte Chemie, Wiley, Vol. 130, No. 37 ( 2018-09-10), p. 12247-12251
Abstract:
Since 1987, stoichiometric cyclomanganation of ketones and subsequent reactions with olefins in the presence of either palladium salts or trimethylamine N ‐oxide (Me 3 N + O − ) have been reported, but the catalytic versions remain untouched so far. Herein, the first manganese‐catalyzed redox‐neutral C−H olefination of ketones with unactivated alkenes is described, and shows a distinct reactivity with its parent stoichimetric reactions. Remarkably, mechanistic experiments and DFT calculations uncovers a unique concerted bis‐metalation deprotonation (CBMD) mechanism of the Mn‐Zn‐enabled C−H bond activation.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.37
DOI:
10.1002/ange.201806287
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505872-7
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1479266-7
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