In:
FEBS Letters, Wiley, Vol. 593, No. 18 ( 2019-09), p. 2612-2627
Abstract:
Mast cells can support the replication of influenza A virus, although how this occurs is poorly understood. In the present study, using quantitative MS, we analyzed the proteome of human mast cells infected with different influenza A virus strains at 12 h post‐infection. Forty‐one differentially expressed proteins were identified in human mast cells upon infection by the virulent H5N1 (A/Chicken/Henan/1/04) virus compared to the seasonal H1N1 (A/WSN/33) virus. Bioinformatic analyses confirmed that H1N1 significantly regulates the RNA degradation pathway via up‐regulation of CCR4‐NOT transcription complex subunit 4, whereas apoptosis could be suppressed by H5N1 via down‐regulation of the tumor protein p53 signaling pathway with P ≤ 0.05 at 12 h post‐infection. The hypoxia‐inducible factor‐1 signaling pathway of human mast cells is more susceptible to infection by H5N1 than by H1N1 virus.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.v593.18
DOI:
10.1002/1873-3468.13523
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1460391-3
SSG:
12
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