In:
Arthritis Research & Therapy, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2021-12)
Abstract:
To investigate the potential utility of quantitative parameters obtained by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in the assessment of disease severity and the occurrence of macrophage activation syndrome (MAS) in adult-onset Still’s disease (AOSD). Methods Fifty-seven patients with AOSD who underwent pre-treatment 18 F-FDG PET/CT were recruited in this study and compared with 60 age- and sex-matched healthy controls. Clinical features and laboratory data were recorded. The systemic score was assessed to determine the disease severity. The maximal standardized uptake value (SUV max ), metabolic lesion volume (MLV), and total lesion glycolysis (TLG) were used to evaluate the involved organs and tissues that abnormally accumulated 18 F-FDG. Multivariate analysis was performed to identify the PET/CT-derived risk factors contributing to the AOSD-related MAS, and their diagnostic efficiency was evaluated. Results High 18 F-FDG accumulation was observed in the bone marrow (SUV max median, 5.10), spleen (SUV max median, 3.70), and lymph nodes (LNs, SUV max median, 5.55). The SUV max of the bone marrow (rho = 0.376, p = 0.004), SUV max of the spleen (rho = 0.450, p 〈 0.001), TLG total of LNs (rho = 0.386, p = 0.017), and MLV total of LNs (rho = 0.391, p = 0.015) were correlated with the systemic score. The SUV max of the spleen ( p = 0.017), TLG total of LNs ( p = 0.045), and MLV total of LNs ( p = 0.012) were higher in patients with MAS than in those without MAS. A MLV total of LNs 〉 62.2 (OR 27.375, p = 0.042) was an independent predictive factor for MAS with a sensitivity of 80.0% and a specificity of 93.9%. Conclusions The glucose metabolic level of the spleen could be an effective and easy-to-use imaging indicator of disease severity, and MLV total of LNs 〉 62.2 was a strong predictor of MAS occurrence in patients with AOSD.
Type of Medium:
Online Resource
ISSN:
1478-6362
DOI:
10.1186/s13075-021-02482-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2041668-4
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