In:
Journal of Cosmetic Dermatology, Wiley, Vol. 19, No. 11 ( 2020-11), p. 2936-2945
Abstract:
Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia‐inducible factor‐1 alpha (HIF‐1α) pathway was linked to both conditions. Recent evidence suggests that modulating this pathway can rejuvenate aged fibroblasts and improve skin regeneration. Here, we describe the application of a novel HIF stimulating factor (HSF™)‐based formulation for skin rejuvenation. Methods Over a period of 6 weeks using a split‐face study design, the effects on skin surface profile, skin moisture, and transepidermal water loss were determined in 32 female subjects (mean age 54, range 32‐67 years) by Fast Optical in vivo Topometry of Human Skin (FOITS HD ), Corneometer, and Tewameter measurements. In addition, a photo documentation was performed for assessment by an expert panel and a survey regarding subject satisfaction was conducted. Results No negative skin reactions of dermatological relevance were documented for the test product. A significant reduction in skin roughness could be demonstrated. The clinical evaluation of the images using a validated method confirmed significant improvement of wrinkles, in particular of fine wrinkles, lip wrinkles, and crow's feet. A significant skin moisturizing effect was detected while skin barrier function was preserved. The HSF™‐based skin care formulation resulted in a self‐reported 94% satisfaction rate. Conclusion With no negative skin reactions and highly significant effects on skin roughness, wrinkles, and moisturization, the HSF™‐based skin care formulation achieved very satisfying outcomes in this clinical trial. Given the favorable results, this approach represents a promising innovation in aesthetic and regenerative medicine.
Type of Medium:
Online Resource
ISSN:
1473-2130
,
1473-2165
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2280551-5
detail.hit.zdb_id:
2075528-4
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