In:
Journal of Applied Toxicology, Wiley, Vol. 31, No. 8 ( 2011-11), p. 762-772
Abstract:
To discover novel endpoints for predicting the irritant potential, proteomics approach was used to analyze the altered protein expression in human keratinocytes exposed to various irritants. The expression of HSP27 and SOD‐1 were down‐regulated, while the expression of CFL‐1 was up‐regulated. HSP27 displayed the most significant alteration both in mRNA and protein levels, accompanying with nuclear translocation. The irritation also induced an increased production of IL1‐. These findings suggest that these proteins may be additional endpoints for skin hazard assessment.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1475015-6
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