In:
EMBO reports, EMBO
Abstract:
image CCDC50 acts as a lypophagy receptor, monitors lysosomal damage induced by metabolic stresses, and clears damaged organelles, which reduces ROS accumulation and supports tumor growth. CCDC50 recognizes and delivers damaged lysosomes to autophagosomes for degradation. The timely clearance of damaged lysosomes by CCDC50‐mediated lysophagy contributes to tumor maintenance and progression. A combination of CCDC50 interference and BRAF inhibitor treatment shows an additive effect on the regression of xenografted tumors.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202356948
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12
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